SLITRK1 Protein, Human (HEK293, His)
Based on 1 Customer Validation
The SLITRK1 protein is critical in synaptogenesis, promoting excitatory synaptic differentiation and synaptic maturation. Its effects extend to enhancing the growth of neuronal dendrites, emphasizing its importance in neuronal development. SLITRK1 Protein, Human (HEK293, His) is the recombinant human-derived SLITRK1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The SLITRK1 protein is critical in synaptogenesis, promoting excitatory synaptic differentiation and synaptic maturation. Its effects extend to enhancing the growth of neuronal dendrites, emphasizing its importance in neuronal development. SLITRK1 Protein, Human (HEK293, His) is the recombinant human-derived SLITRK1 protein, expressed by HEK293 , with C-His labeled tag.
Background
SLITRK1 plays a crucial role in synaptogenesis, actively promoting the differentiation of excitatory synapses, as evidenced by its involvement in synaptic maturation. Additionally, SLITRK1 contributes to the enhancement of neuronal dendrite outgrowth, underscoring its significance in neuronal development and morphology. The protein is capable of forming homodimers, with this dimerization process specifically dependent on the presence of the repeat LRR 2 domain. Moreover, SLITRK1 interacts with various members of the 14-3-3 protein family, including YWHAB, YWHAE, YWHAG, YWHAH, SFN, YWHAQ, and YWHAZ, suggesting potential regulatory roles and cellular functions mediated by these interactions.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His
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Accession
Q96PX8 (N18-S616)
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Molecular Construction
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N-term
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SLITRK1 (N18-S616)
Accession # Q96PX8 -
His
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C-term
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Protein Length
Partial Extracellular Domain
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Synonyms
SLITRK1; SLIT And NTRK-Like Protein 1; Prev. LRRC12; Leucine Rich Repeat Containing 12; KIAA1910; Slit And Trk Like Gene 1; Leucine-Rich Repeat-Containing Protein 12; TTM; SLIT And NTRK Like Family Member 1; SLIT And NTRK-Like Family, Member 1
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AA Sequence
NVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVS
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Molecular Weight
Approximately 105-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (238 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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