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Hnrnpk - heterogeneous nuclear ribonucleoprotein K Gene

Also Known as Csbp; Hnrpk

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 117282

Summary

Enables several functions, including ATPase binding activity; lamin binding activity; and nucleic acid binding activity. Involved in several processes, including animal organ development; cellular response to organonitrogen compound; and regulation of synapse organization. Located in several cellular components, including axon terminus; dendritic spine; and postsynaptic density. Part of protein-DNA complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpk Products (1)

mRNA	Protein	Name
NM_057141.1	NP_476482.1	heterogeneous nuclear ribonucleoprotein K

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	23159318	RGD
enables C-rich single-stranded DNA binding	IDA IDA: Inferred from direct assay	8127654	RGD
enables actinin binding	IPI IPI: Inferred from physical interaction	16518874	RGD
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15361071	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	16519889	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	16518874	RGD
enables lamin binding	IPI IPI: Inferred from physical interaction	16518874	RGD
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	15485813	RGD
enables mRNA CDS binding	IDA IDA: Inferred from direct assay	16980303	RGD
enables pre-mRNA 3'-splice site binding	IDA IDA: Inferred from direct assay	22684629	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16518874	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9553145	RGD
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	9553145	RGD
enables ribonucleoprotein complex binding	IPI IPI: Inferred from physical interaction	15303970	RGD
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	15361071	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	9553145	RGD
involved in camera-type eye development	IEP IEP: Inferred from expression pattern	16488668	RGD
involved in cellular response to amino acid stimulus	IEP IEP: Inferred from expression pattern	24990929	RGD
involved in cellular response to forskolin	IDA IDA: Inferred from direct assay	22684629	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	16837467	RGD
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	15485813	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	16837467	RGD
involved in cellular response to lead ion	IEP IEP: Inferred from expression pattern	33576715	RGD
involved in cellular response to rapamycin	IEP IEP: Inferred from expression pattern	24108520	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	22102872	RGD
involved in cerebral cortex development	IDA IDA: Inferred from direct assay	18054780	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	22102872	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	22102872	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	16488668	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	16488668	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	16488668	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	30450874	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	24990929	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	24990929	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21190960	RGD
involved in negative regulation of branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	22102872	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	9553145	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16837467	RGD
involved in ovarian follicle development	IMP IMP: Inferred from mutant phenotype	21190960	RGD
involved in peripheral nervous system development	IEP IEP: Inferred from expression pattern	16488668	RGD
involved in positive regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	22684629	RGD
involved in positive regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	24990929	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	24990929	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	24990929	RGD
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	21357748	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	22684629	RGD
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	24990929	RGD
involved in positive regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	22102872	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	24990929	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	24990929	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	24990929	RGD
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21190960	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	18230368	RGD
involved in response to salt	IEP IEP: Inferred from expression pattern	18316652	RGD
involved in thymus development	IEP IEP: Inferred from expression pattern	16488668	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon terminus	IDA IDA: Inferred from direct assay	22102872	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	16518874	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	24990929	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24990929	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24990929	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	24990929	RGD
part of protein-DNA complex	IDA IDA: Inferred from direct assay	9553145	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
heterogeneous nuclear ribonucleoprotein K	dC stretch-binding protein hnRNP K

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135691	hnRNPK-IN-1		97.0%	Unkown
HY-RS06273	HNRNPK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21137	Hnrnpk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27655	Hnrnpk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnrnpk	NCBI	NCBI:3190