Casp12 - caspase 12 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12364

About Casp12

Chromosome 9: 5,345,430-5,373,032 forward strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 273 orthologues, 11 paralogues and is associated with 9 phenotypes. Biased expression in bladder adult (RPKM 12.1), subcutaneous fat pad adult (RPKM 1.5) and 5 other tissues.

Summary

Enables cysteine-type endopeptidase activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and self proteolysis. Acts upstream of or within apoptotic process and endoplasmic reticulum unfolded protein response. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human CASP12 (Caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]

Casp12 Products (1)

mRNA Protein Name
NM_009808.4 NP_033938.3 caspase-12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
12097332 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11278723 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within endoplasmic reticulum unfolded protein response IDA
IDA: Inferred from direct assay
10882126 MGI
acts upstream of or within fibroblast apoptotic process IDA
IDA: Inferred from direct assay
12847083 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
12097332 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
IGI: Inferred from genetic interaction
12847083 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
10638761 MGI
involved in self proteolysis IDA
IDA: Inferred from direct assay
12097332 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10638761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp12 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (5 - 87)

CASc

CASc: smart00115 (165 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

caspase-12

  • CASP-12

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp12 NCBI NCBI:100506742