NRN1L - neuritin 1 like Gene

Also Known as UNQ2446; cpg15-2; MRCC2446

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 123904

About NRN1L

This gene has 3 transcripts (splice variants), 255 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is extracellular and enhances both neurite growth and neuronal survival. The encoded protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. [provided by RefSeq, Feb 2017]

NRN1L Products (2)

mRNA Protein Name
NM_001348682.2 NP_001335611.1 neuritin-like protein isoform 2 precursor
NM_198443.2 NP_940845.1 neuritin-like protein isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRN1L Protein Structure

NRN1

NRN1: Neuritin protein family (42 - 118)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

neuritin-like protein

NRN1L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NRN1L Q496H8 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRN1L Proteins

Cat. No. Product Name Accession Purity
HY-P71172 NRN1L Protein, Human (HEK293, His) Q496H8 (A36-A139) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09578 NRN1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20070 Nrn1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26574 Nrn1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28672 Edc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NRN1L RGD RGD:2301010
Mus musculus NRN1L MGD MGI:2443642
Macaca mulatta NRN1L VGNC VGNC:99531
Bos taurus NRN1L VGNC VGNC:106848
Felis catus NRN1L VGNC VGNC:63882
Others NRN1L NCBI