PACRG - parkin coregulated Gene

Also Known as GLUP; PACRG2.1; PARK2CRG; HAK005771

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 135138

About PACRG

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:162,727,132-163,315,500 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PACRG Products (3)

mRNA	Protein	Name
NM_001080378.2	NP_001073847.1	parkin coregulated gene protein isoform 2
NM_001080379.2	NP_001073848.1	parkin coregulated gene protein isoform 2
NM_152410.3	NP_689623.2	parkin coregulated gene protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	14532270	GOA
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	14532270	GOA
enables actin binding	IDA IDA: Inferred from direct assay	14532270	GOA
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	14532270	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	14532270	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	14532270	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axonemal microtubule	IDA IDA: Inferred from direct assay	36191189	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14532270	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	14532270	GOA
located in vesicle	IDA IDA: Inferred from direct assay	14532270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PACRG Protein Structure

ParcG

0
100
200
296 a.a.

Protein Preferred Names	Protein Names
parkin coregulated gene protein	PARK2 co-regulated

PACRG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PACRG	Q96M98	KLHL36	Homo sapiens	Q8N4N3	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Parkin Type Of Early-Onset Parkinson Disease	Park-Parkin Prkn Parkinson Disease
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Dermatitis, Atopic, 3	ATOD3 Dermatitis, Atopic, Susceptibility To, 3 Atopic Dermatitis 3 Dermatitis, Atopic, With Asthma Dermatitis, Atopic 3 Atopic Dermatitis With Asthma
Indeterminate Leprosy	Uncharacteristic Leprosy
Tuberculoid Leprosy	Smooth Leprosy Type T Leprosy Leprosy Tuberculoid Leprosy, Tuberculoid
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Paratyphoid Fever	Paratyphoid B Fever Paratyphoid C Fever Paratyphoid Fever A Paratyphoid Fever B Paratyphoid Fever C Paratyphoid Paratyphoid A Paratyphoid A Fever Paratyphoid B Paratyphoid C Infection Due To Salmonella Paratyphi
Lepromatous Leprosy	Leprosy, Lepromatous Type L Leprosy Leprosy Lepromatous
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Epilepsy, Myoclonic Juvenile	Juvenile Myoclonic Epilepsy Janz Syndrome Jme Myoclonic Epilepsy, Juvenile, Susceptibility To, 1 EJM Myoclonic Epilepsy, Juvenile Petit Mal, Impulsive Myoclonic Epilepsy, Juvenile 1 Myoclonic Epilepsy, Juvenile, 1 Adolescent Myoclonic Epilepsy Juvenile Myoclonus Epilepsy Juvenile Myoclonic Epilepsy 1 EJM1 Petit Mal Impulsive Susceptibility To Juvenile Myoclonic Epilepsy 1 Myoclonic Epilepsy Juvenile Epilepsy, Myoclonic, Juvenile Myoclonic Epilepsy Of Janz Jme - [Juvenile Myoclonic Epilepsy]
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09954	PACRG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PACRG	VGNC	VGNC:75646
Bos taurus	PACRG	VGNC	VGNC:55070
Mus musculus	PACRG	MGD	MGI:1916560
Felis catus	PACRG	VGNC	VGNC:102479
Rattus norvegicus	PACRG	RGD	RGD:1561027
Others	PACRG	NCBI