Fzd9 - frizzled class receptor 9 Gene

Also Known as Fz9; mfz9

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14371

Summary

Enables Wnt-activated receptor activity. Involved in several processes, including bone regeneration; negative regulation of skeletal muscle acetylcholine-gated channel clustering; and positive regulation of bone mineralization. Acts upstream of or within B cell differentiation; learning or memory; and neuroblast proliferation. Located in filopodium membrane and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; gonad; sensory organ; and skeleton. Used to study Williams-Beuren syndrome. Orthologous to human FZD9 (Frizzled class receptor 9). [provided by Alliance of Genome Resources, Apr 2022]

Fzd9 Products (1)

mRNA	Protein	Name
NM_010246.1	NP_034376.1	frizzled-9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	24860427	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	15572594	MGI
involved in bone regeneration	IMP IMP: Inferred from mutant phenotype	24391920	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	15930120	MGI
involved in negative regulation of skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	24860427	MGI
acts upstream of or within neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15930120	MGI
involved in ossification	IMP IMP: Inferred from mutant phenotype	21402791	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	21402791	MGI
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24860427	MGI
involved in regulation of skeletal muscle acetylcholine-gated channel clustering	IDA IDA: Inferred from direct assay	24860427	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in filopodium membrane	IDA IDA: Inferred from direct assay	10198163	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10198163	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10198163	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
frizzled-9	frizzled homolog 9 fz-9 mFz3

Recombinant Fzd9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79115	Frizzled-9 Protein, Mouse (HEK293, mFc)	Q9R216 (L24-D186)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05185	FZD9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21344	Fzd9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27863	Fzd9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fzd9	NCBI	NCBI:8326