Myo9b - myosin IXb Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17925

Summary

Enables GTPase activator activity and microfilament motor activity. Acts upstream of or within several processes, including Rho protein signal transduction; lamellipodium morphogenesis; and leukocyte chemotaxis. Located in filopodium tip; lamellipodium; and ruffle. Is expressed in brain; cerebellum; heart; inner ear; and skeletal muscle. Human ortholog(s) of this gene implicated in celiac disease. Orthologous to human MYO9B (Myosin IXB). [provided by Alliance of Genome Resources, Apr 2022]

Myo9b Products (2)

mRNA Protein Name
NM_001142322.2 NP_001135794.1 unconventional myosin-IXb isoform 1
NM_001142323.2 NP_001135795.1 unconventional myosin-IXb isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
17314409 MGI
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
20566876 MGI
enables microfilament motor activity IDA
IDA: Inferred from direct assay
17314409 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
20566876 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
20566876 MGI
acts upstream of or within lamellipodium morphogenesis IMP
IMP: Inferred from mutant phenotype
20566876 MGI
acts upstream of or within macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
20566876 MGI
acts upstream of or within monocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
20566876 MGI
acts upstream of or within positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
17314409 MGI
acts upstream of or within positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
20566876 MGI
Cellular Component GO Annotation Evidence References Source
located in filopodium tip IDA
IDA: Inferred from direct assay
17314409 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
17314409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-IXb

  • unconventional myosin-9b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08953 MYO9B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22665 Myo9b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29179 Myo9b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo9b NCBI NCBI:4650