Npy2r - neuropeptide Y receptor Y2 Gene

Also Known as NPY2-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18167

About Npy2r

Chromosome 3: 82,445,690-82,455,391 reverse strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 248 orthologues, 55 paralogues and is associated with 40 phenotypes. Biased expression in adrenal adult (RPKM 1.5), genital fat pad adult (RPKM 1.1) and 11 other tissues.

Summary

Enables peptide YY receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is expressed in central nervous system; dorsal root ganglion; eye; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (Neuropeptide Y Receptor Y2). [provided by Alliance of Genome Resources, Apr 2022]

Npy2r Products (5)

mRNA Protein Name
NM_001410444.1 NP_001397373.1 neuropeptide Y receptor type 2 isoform 1
NM_001410445.1 NP_001397374.1 neuropeptide Y receptor type 2 isoform 1
NM_008731.4 NP_032757.2 neuropeptide Y receptor type 2 isoform 1
NM_001205099.2 NP_001192028.1 neuropeptide Y receptor type 2 isoform 2
NM_001410443.1 NP_001397372.1 neuropeptide Y receptor type 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropeptide Y receptor activity IDA
IDA: Inferred from direct assay
10698177 MGI
enables peptide YY receptor activity IDA
IDA: Inferred from direct assay
10698177 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24316073 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
24316073 MGI
Cellular Component GO Annotation Evidence References Source
is active in cilium IDA
IDA: Inferred from direct assay
26053317 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
24316073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Npy2r Protein Structure

7tmA_NPY2R

7tmA_NPY2R: cd15399 (50 - 335)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (51 - 77)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (84 - 109)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (122 - 152)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (163 - 184)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (215 - 244)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (260 - 290)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (303 - 328)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 2

  • NPY-Y2 receptor

  • Y2 receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101986 BIIE-0246 Antagonist 99.10% Unkown
HY-101986A BIIE-0246 hydrochloride Antagonist 99.33% Unkown
HY-RS09514 NPY2R Human Pre-designed siRNA Set A / Unkown
HY-RS09515 Npy2r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09516 NPY2R Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npy2r NCBI NCBI:4887