Polb - polymerase (DNA directed), beta Gene

Also Known as A430088C08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18970

Summary

Predicted to enable several functions, including DNA-directed DNA Polymerase activity; damaged DNA binding activity; and microtubule binding activity. Acts upstream of or within several processes, including base-excision repair, gap-filling; immune system development; and intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm and spindle microtubule. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in early conceptus; hemolymphoid system; muscle tissue; nervous system; and sensory organ. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human POLB (DNA Polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]

Polb Products (1)

mRNA Protein Name
NM_011130.2 NP_035260.1 DNA polymerase beta

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within base-excision repair, gap-filling IMP
IMP: Inferred from mutant phenotype
15177179 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within immunoglobulin heavy chain V-D-J recombination IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
10197627 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15485914 MGI
acts upstream of or within salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within somatic diversification of immunoglobulins IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
24388753 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
24388753 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase beta

  • Pol beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10818 POLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10830 POLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19369 Polb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25861 Polb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polb NCBI NCBI:5423