ETV5 - ETS variant transcription factor 5 Gene

Also Known as ERM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2119

About ETV5

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:186,046,314-186,109,089 (from NCBI)

This gene has 14 transcripts (splice variants), 131 orthologues, 28 paralogues and is associated with 62 phenotypes. Broad expression in brain (RPKM 25.8), adrenal (RPKM 22.0) and 23 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to oxidative stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ETV5 Products (1)

mRNA Protein Name
NM_004454.3 NP_004445.1 ETS translocation variant 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15857832 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19443906 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
15857832 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17126306 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19443906 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
19443906 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17126306 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15857832 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19443906 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETV5 Protein Structure

ETS_PEA3_N

ETS_PEA3_N: PEA3 subfamily ETS-domain transcription factor N terminal domain (1 - 366)

Ets

Ets: Ets-domain (368 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

ETS translocation variant 5

  • ets-related molecule

ETV5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ETV5 P41161 COP1 Homo sapiens Q8NHY2
BioID
35140242
Intra
ETV5 P41161 COP1 Homo sapiens Q8NHY2
Affinity Chrom
35140242
Intra
ETV5 P41161 COP1 Homo sapiens Q8NHY2
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

ETV5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84301 ERM/Etv5 Antibody (YA3998) WB, ELISA Human
HY-P84301A ERM/Etv5 Antibody (YA3998)(PBS only) WB, ELISA Human
HY-P85153 ERM/Etv5 Antibody (YA4845) WB, ELISA Human
HY-P86864 ERM/Etv5 Antibody (YA6557) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Acoustic Neuroma

  • Neurofibromatosis Type 2

  • Vestibular Schwannoma

  • Acoustic Neurinoma

  • Bilateral Acoustic Neurofibromatosis

  • Nf2

  • Acoustic Neurilemoma

  • Cerebellopontine Angle Tumor

  • Neurofibromatosis Central Type

  • Neurofibromatosis Type Ii

  • Vestibular Neurilemmoma

  • Acoustic Tumor

  • Neurinoma Of The Acoustic Nerve

  • Acoustic Neurinoma Bilateral

  • Acoustic Schwannomas Bilateral

  • Banf

  • Central Neurofibromatosis

  • Familial Acoustic Neuromas

  • Neurofibromatosis 2

  • Neurofibromatosis Type 2 Merlin

  • Schwannoma, Acoustic, Bilateral

  • Neuroma Acoustic

  • Neuroma, Acoustic

  • Familial Acoustic Neuroma

  • Familial Vestibular Schwannoma

  • Neurofibromatosis, Central Type

  • Nf2 - [Neurofibromatosis Type 2]
Charcot-Marie-Tooth Disease, Axonal, Type 2dd

  • CMT2DD

  • Charcot-Marie-Tooth Neuropathy, Type 2dd

  • Charcot-Marie-Tooth Disease Type 2dd

  • Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

  • Atp1a1-Related Cmt2

  • Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd

  • Charcot-Marie-Tooth Disease 2dd
Lacrimoauriculodentodigital Syndrome

  • Ladd Syndrome

  • Levy-Hollister Syndrome

  • Lacrimo-Auriculo-Dento-Digital Syndrome

  • LADD

  • Lacrimoauriculodento-Digital Syndrome

  • Levy Hollister Syndrome

  • Lard Syndrome

  • Lacrimoauriculoradiodental Syndrome

  • LADDS

  • Congenital Duodenal Obstruction Due To Malrotation Of Intestine
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-174866 BT-O2C Inhibitor 99.31% Unkown
HY-RS04568 ETV5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21338 Etv5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27857 Etv5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ETV5 VGNC VGNC:40499
Rattus norvegicus ETV5 RGD RGD:1309590
Mus musculus ETV5 MGD MGI:1096867
Felis catus ETV5 VGNC VGNC:61985
Macaca mulatta ETV5 VGNC VGNC:72443
Bos taurus ETV5 VGNC VGNC:28631
Others ETV5 NCBI