Cntn2 - contactin 2 Gene

Also Known as Tax; TAG1; TAG-1; D130012K04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21367

Summary

This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. Mice lacking a functional copy of this gene exhibit epileptic seizures and elevated expression of A1 adenosine receptors. [provided by RefSeq, Sep 2016]

Cntn2 Products (1)

mRNA Protein Name
NM_177129.5 NP_796103.2 contactin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbohydrate binding IDA
IDA: Inferred from direct assay
19458237 MGI
enables cell adhesion mediator activity IMP
IMP: Inferred from mutant phenotype
18650339 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18550718 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of G protein-coupled adenosine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11178983 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
18760366 MGI
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
18550718 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
18550718 MGI
acts upstream of or within axonal fasciculation IMP
IMP: Inferred from mutant phenotype
18650339 MGI
acts upstream of or within central nervous system myelination IMP
IMP: Inferred from mutant phenotype
18650339 MGI
acts upstream of or within cerebral cortex GABAergic interneuron migration IMP
IMP: Inferred from mutant phenotype
11714688 MGI
involved in clustering of voltage-gated potassium channels IMP
IMP: Inferred from mutant phenotype
12963709 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
18550718 MGI
involved in establishment of protein localization to juxtaparanode region of axon IDA
IDA: Inferred from direct assay
12975355 MGI
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
22752552 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
18760366 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
18650339 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
18278038 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
18278038 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
11807022 MGI
acts upstream of or within neuron projection development IGI
IGI: Inferred from genetic interaction
19458237 MGI
acts upstream of or within positive regulation of adenosine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11178983 MGI
acts upstream of or within positive regulation of protein processing IDA
IDA: Inferred from direct assay
18278038 MGI
acts upstream of or within protein localization to juxtaparanode region of axon IGI
IGI: Inferred from genetic interaction
20962216 MGI
acts upstream of or within protein localization to juxtaparanode region of axon IMP
IMP: Inferred from mutant phenotype
18760366 MGI
involved in protein localization to juxtaparanode region of axon IMP
IMP: Inferred from mutant phenotype
12963709 MGI
acts upstream of protein processing IDA
IDA: Inferred from direct assay
18278038 MGI
acts upstream of or within receptor internalization IDA
IDA: Inferred from direct assay
18550718 MGI
involved in reduction of food intake in response to dietary excess IMP
IMP: Inferred from mutant phenotype
22752552 MGI
acts upstream of or within regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18650339 MGI
acts upstream of or within regulation of axon diameter IMP
IMP: Inferred from mutant phenotype
18650339 MGI
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18650339 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11178983 MGI
involved in response to dietary excess IMP
IMP: Inferred from mutant phenotype
22752552 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
8089271 MGI
is active in axon initial segment IDA
IDA: Inferred from direct assay
18509034 MGI
located in cell surface IDA
IDA: Inferred from direct assay
8089271 MGI
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
12963709 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
12963709 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
18650339 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
8089271 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
12963709 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

contactin-2

  • TAX-1

  • axonal glycoprotein TAG-1

  • axonin

  • axonin-1

  • transient axonal glycoprotein 1

Recombinant Cntn2 Proteins

Cat. No. Product Name Accession Purity
HY-P74223 Contactin-2/CNTN2 Protein, Mouse (HEK293, His) Q61330 (Q31-E1013) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02927 CNTN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19999 Cntn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26502 Cntn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cntn2 NCBI NCBI:6900