FCAR - Fc alpha receptor Gene

Also Known as CD89; FcalphaR; FcalphaRI; CTB-61M7.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2204

About FCAR

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,874,235-54,891,420 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 69 orthologues and 25 paralogues. Restricted expression toward bone marrow (RPKM 95.4).

Summary

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a Transmembrane Glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

FCAR Products (8)

mRNA Protein Name
NM_002000.4 NP_001991.1 immunoglobulin alpha Fc receptor isoform a precursor
NM_133269.4 NP_579803.1 immunoglobulin alpha Fc receptor isoform b precursor
NM_133271.4 NP_579805.1 immunoglobulin alpha Fc receptor isoform c precursor
NM_133272.4 NP_579806.1 immunoglobulin alpha Fc receptor isoform d
NM_133273.4 NP_579807.1 immunoglobulin alpha Fc receptor isoform e
NM_133274.4 NP_579808.1 immunoglobulin alpha Fc receptor isoform f
NM_133277.4 NP_579811.1 immunoglobulin alpha Fc receptor isoform g
NM_133278.4 NP_579812.1 immunoglobulin alpha Fc receptor isoform h

FCAR Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (29 - 117)

Ig_2

Ig_2: Immunoglobulin domain (126 - 215)

  • 0
  • 100
  • 200
  • 287 a.a.
Protein Preferred Names Protein Names

immunoglobulin alpha Fc receptor

  • Fc fragment of IgA receptor

Recombinant FCAR Proteins

Cat. No. Product Name Accession Purity
HY-P72657 FCAR/CD89 Protein, Human (HEK293, His) P24071-1 (Q22-N227) ≥ 95%, as determined by reducing SDS-PAGE.

FCAR Antibodies

Cat. No. Product Name Application Reactivity
HY-P82215 CD89 Antibody (YA1960) WB, IHC-P, ICC/IF, IP, FC Human
HY-P86256 CD89 Antibody (YA5948) WB, IHC-P, ICC/IF, FC, IP Human

Related Diseases

Diseases Alias
Iga Glomerulonephritis

  • Iga Nephropathy

  • Glomerulonephritis, Iga

  • Berger'S Iga Or Igg Nephropathy

  • Focal Glomerulonephritis

  • Primary Iga Nephropathy

  • Segmental Glomerulonephritis

  • Berger Disease

  • Berger'S Disease

  • Igan

  • Nephritis, Iga Type

  • Nephropathy Iga

  • Glomerulonephritis Focal

  • Iga Nephropathy, Susceptibility To

  • Primary Immunoglobulin A Nephropathy
Alcoholic Liver Cirrhosis

  • Alcoholic Cirrhosis

  • Portal Cirrhosis

  • Alcoholic Cirrhosis Of Liver

  • Liver Cirrhosis, Alcoholic

  • Laennec'S Cirrhosis

  • Laennec'S Cirrhosis, Alcoholic

  • Alcohol Cirrhosis

  • Alcoholic Laennec Cirrhosis

  • Alcoholic Cirrhosis Nos

  • Etoh Cirrhosis

  • Alcohol Hepatic Cirrhosis

  • Alcohol Liver Cirrhosis

  • Laennec Cirrhosis
Glomerulonephritis

  • Bright'S Disease
Erythema Elevatum Diutinum
Hypersensitivity Vasculitis

  • Cutaneous Small Vessel Vasculitis

  • Hypersensitivity Angiitis

  • Cutaneous Leukocytoclastic Vasculitis

  • Leukocytoclastic Angiitis

  • Vasculitis, Leukocytoclastic, Cutaneous

  • Leukocytoclastic Vasculitis

  • Cutaneous Leukocytoclastic Angiitis

  • Cutaneous Hypersensitivity Vasculitis

  • Vasculitis Hypersensitivity

  • Drug Induced Cutaneous Vasculitis

  • Allergic Vasculitis
Inflammatory Bowel Disease 10

  • Inflammatory Bowel Disease 10

  • IBD10

  • Inflammatory Bowel Disease 10, Susceptibility To

  • Bowel Disease, Inflammatory, Type 10
Hypersensitivity Reaction Type Iii Disease

  • Immune Complex Diseases

  • Immune Complex Disease

  • Type Iii Hypersensitivity Reaction Disease
Henoch-Schoenlein Purpura

  • Henoch-Schonlein Purpura

  • Iga Vasculitis

  • Allergic Purpura

  • Anaphylactoid Purpura

  • Rheumatoid Purpura

  • Immunoglobulin A Vasculitis

  • Vascular Purpura

  • Purpura Rheumatica

  • Henoch-Schönlein Purpura

  • Autoimmune Purpura

  • Henoch-Schnlein Purpura

  • Henoch-Sch@Nlein Purpura

  • Henoch-Scholein Purpura

  • Purpura, Autoimmune

  • Henoch Schonlein Purpura

  • Immunoglobulin-A Vasculitis

  • Purpura, Schonlein-Henoch

  • Purpura, Schönlein-Henoch

  • Hsp -

  • Schönlein-Henoch Purpura
Immunoglobulin Alpha Deficiency

  • Iga Deficiency

  • Gamma-A-Globulin Deficiency

  • Immunoglobulin A Deficiency
Spondyloarthropathy 1

  • Ankylosing Spondylitis

  • Spondyloarthropathy, Susceptibility To, 1

  • SPDA1

  • Marie-Strumpell Spondylitis

  • Bechterew Syndrome

  • Spa

  • Spondylarthritis Ankylopoietica

  • Reiter Syndrome

  • Ankylosing Spondylitis, Susceptibility To

  • Bekhterev Syndrome

  • Bekhterev'S Disease

  • Marie-Strumpell Disease

  • Axial Spondylarthritis

  • Bechterew Disease

  • Marie-Struempell Disease

  • Spondylitis Ankylopoietica

  • Spondyloarthritis

  • Spondyloarthritis Ankylopoietica

  • Spas

  • Ankylosing Spondylarthritis

  • Psoriatic Arthritis

  • Reactive Arthritis

  • Rheumatoid Spondylitis

  • Spondylitis Ankylosans

  • Spondylitis Ankylosing

  • Spondylitis, Ankylosing

  • Spondylarthropathies

  • Arthritis, Psoriatic

  • Arthritis, Reactive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04821 FCAR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24606 Fcar Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991705 Nebaprubart Inhibitor 96.95% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FCAR VGNC VGNC:72627
Rattus norvegicus FCAR RGD RGD:1303082
Bos taurus FCAR VGNC VGNC:28929
Others FCAR NCBI