FCAR - Fc alpha receptor Gene

Homo sapiens

Also known as CD89; FcalphaR; FcalphaRI; CTB-61M7.2

Gene ID: 2204 | Gene type: protein coding

About FCAR

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,874,235-54,891,420 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 69 orthologues and 25 paralogues. Restricted expression toward bone marrow (RPKM 95.4).

Summary

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

FCAR Products(8)

mRNA	Protein	Name
NM_002000.4	NP_001991.1	immunoglobulin alpha Fc receptor isoform a precursor
NM_133269.4	NP_579803.1	immunoglobulin alpha Fc receptor isoform b precursor
NM_133271.4	NP_579805.1	immunoglobulin alpha Fc receptor isoform c precursor
NM_133272.4	NP_579806.1	immunoglobulin alpha Fc receptor isoform d
NM_133273.4	NP_579807.1	immunoglobulin alpha Fc receptor isoform e
NM_133274.4	NP_579808.1	immunoglobulin alpha Fc receptor isoform f
NM_133277.4	NP_579811.1	immunoglobulin alpha Fc receptor isoform g
NM_133278.4	NP_579812.1	immunoglobulin alpha Fc receptor isoform h

FCAR Protein Structure

Ig_2

0
100
200
287 a.a.

Protein Preferred Names

Protein Names

immunoglobulin alpha Fc receptor

Fc fragment of IgA receptor

Recombinant FCAR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72657	FCAR/CD89 Protein, Human (HEK293, His)	P24071 (Q22-N227)	≥95%
HY-P75374	FCAR/CD89 Protein, Human (227a.a, HEK293, His)	P24071 (M1-N227)	≥95%

Related Diseases

Diseases

Alias

Iga Glomerulonephritis

Iga Nephropathy	Glomerulonephritis, Iga
Berger'S Iga Or Igg Nephropathy	Focal Glomerulonephritis
Primary Iga Nephropathy	Segmental Glomerulonephritis
Berger Disease	Berger'S Disease
Igan	Nephritis, Iga Type
Nephropathy Iga	Glomerulonephritis Focal
Iga Nephropathy, Susceptibility To	Primary Immunoglobulin A Nephropathy

Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis	Portal Cirrhosis
Alcoholic Cirrhosis Of Liver	Liver Cirrhosis, Alcoholic
Laennec'S Cirrhosis	Laennec'S Cirrhosis, Alcoholic
Alcohol Cirrhosis	Alcoholic Laennec Cirrhosis
Alcoholic Cirrhosis Nos	Etoh Cirrhosis
Alcohol Hepatic Cirrhosis	Alcohol Liver Cirrhosis
Laennec Cirrhosis

Glomerulonephritis

Bright'S Disease

Erythema Elevatum Diutinum

Hypersensitivity Vasculitis

Cutaneous Small Vessel Vasculitis	Hypersensitivity Angiitis
Cutaneous Leukocytoclastic Vasculitis	Leukocytoclastic Angiitis
Vasculitis, Leukocytoclastic, Cutaneous	Leukocytoclastic Vasculitis
Cutaneous Leukocytoclastic Angiitis	Cutaneous Hypersensitivity Vasculitis
Vasculitis Hypersensitivity	Drug Induced Cutaneous Vasculitis
Allergic Vasculitis

Inflammatory Bowel Disease 10

Inflammatory Bowel Disease 10	IBD10
Inflammatory Bowel Disease 10, Susceptibility To	Bowel Disease, Inflammatory, Type 10

Hypersensitivity Reaction Type Iii Disease

Immune Complex Diseases	Immune Complex Disease
Type Iii Hypersensitivity Reaction Disease

Henoch-Schoenlein Purpura

Henoch-Schonlein Purpura	Iga Vasculitis
Allergic Purpura	Anaphylactoid Purpura
Rheumatoid Purpura	Immunoglobulin A Vasculitis
Vascular Purpura	Purpura Rheumatica
Henoch-Schönlein Purpura	Autoimmune Purpura
Henoch-Schnlein Purpura	Henoch-Sch@Nlein Purpura
Henoch-Scholein Purpura	Purpura, Autoimmune
Henoch Schonlein Purpura	Immunoglobulin-A Vasculitis
Purpura, Schonlein-Henoch	Purpura, Schönlein-Henoch
Hsp -	Schönlein-Henoch Purpura

Immunoglobulin Alpha Deficiency

Iga Deficiency	Gamma-A-Globulin Deficiency
Immunoglobulin A Deficiency

Spondyloarthropathy 1

Ankylosing Spondylitis	Spondyloarthropathy, Susceptibility To, 1
SPDA1	Marie-Strumpell Spondylitis
Bechterew Syndrome	Spa
Spondylarthritis Ankylopoietica	Reiter Syndrome
Ankylosing Spondylitis, Susceptibility To	Bekhterev Syndrome
Bekhterev'S Disease	Marie-Strumpell Disease
Axial Spondylarthritis	Bechterew Disease
Marie-Struempell Disease	Spondylitis Ankylopoietica
Spondyloarthritis	Spondyloarthritis Ankylopoietica
Spas	Ankylosing Spondylarthritis
Psoriatic Arthritis	Reactive Arthritis
Rheumatoid Spondylitis	Spondylitis Ankylosans
Spondylitis Ankylosing	Spondylitis, Ankylosing
Spondylarthropathies	Arthritis, Psoriatic
Arthritis, Reactive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04821	FCAR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FCAR	VGNC	VGNC:72627
Rattus norvegicus	FCAR	RGD	RGD:1303082
Bos taurus	FCAR	VGNC	VGNC:28929
Others	FCAR	NCBI