KIF6 - kinesin family member 6 Gene
Also Known as C6orf102; dJ137F1.4; dJ188D3.1; dJ1043E3.1
Species: Homo sapiens
About KIF6
This gene has 8 transcripts (splice variants), 197 orthologues and 41 paralogues. Biased expression in testis (RPKM 1.6), brain (RPKM 1.0) and 4 other tissues.
Summary
This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and Other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]
KIF6 Products (13)
| mRNA | Protein | Name |
|---|---|---|
| XM_047418330.1 | XP_047274286.1 | kinesin-like protein KIF6 isoform X4 |
| XR_001743238.2 | ||
| NM_145027.6 | NP_659464.3 | kinesin-like protein KIF6 isoform 1 |
| XM_047418331.1 | XP_047274287.1 | kinesin-like protein KIF6 isoform X6 |
| NM_001289020.3 | NP_001275949.1 | kinesin-like protein KIF6 isoform 2 |
| XM_011514361.3 | XP_011512663.1 | kinesin-like protein KIF6 isoform X5 |
| NM_001289021.3 | NP_001275950.1 | kinesin-like protein KIF6 isoform 3 |
| XM_011514358.4 | XP_011512660.1 | kinesin-like protein KIF6 isoform X3 |
| XM_005248904.5 | XP_005248961.1 | kinesin-like protein KIF6 isoform X1 |
| NM_001351503.2 | NP_001338432.1 | kinesin-like protein KIF6 isoform 6 |
| NM_001289024.3 | NP_001275953.1 | kinesin-like protein KIF6 isoform 4 |
| NM_001351566.2 | NP_001338495.1 | kinesin-like protein KIF6 isoform 5 |
| XM_011514357.4 | XP_011512659.1 | kinesin-like protein KIF6 isoform X2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
KIF6 Protein Structure
Kinesin: Kinesin motor domain (47 - 343)
- 0
- 200
- 400
- 600
- 814 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
kinesin-like protein KIF6 |
|
KIF6 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KIF6 | Q6ZMV9 | APPBP2 | Homo sapiens | Q92624 | 19060904 | |
|
Intra
|
KIF6 | Q6ZMV9 | APPBP2 | Homo sapiens | Q92624 | 19060904 | |
|
Intra
|
KIF6 | Q6ZMV9 | APPBP2 | Homo sapiens | Q92624 | 16189514 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Heart Disease |
|
|
| Smallpox |
|
|
| Idiopathic Scoliosis |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | KIF6 | VGNC | VGNC:73873 |
| Canis familiaris | KIF6 | VGNC | VGNC:42410 |
| Mus musculus | KIF6 | MGD | MGI:1098238 |
| Felis catus | KIF6 | VGNC | VGNC:63118 |
| Rattus norvegicus | KIF6 | RGD | RGD:621070 |
| Bos taurus | KIF6 | VGNC | VGNC:106795 |
| Others | KIF6 | NCBI |