FLG - filaggrin Gene

Also Known as FLG1; ATOD2; FLG-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2312

About FLG

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,302,165-152,325,239 (from NCBI)

This gene has 1 transcript (splice variant), 25 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward skin (RPKM 454.2).

Summary

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

FLG Products (1)

mRNA	Protein	Name
NM_002016.2	NP_002007.1	filaggrin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23629652	GOA
enables structural constituent of skin epidermis	IDA IDA: Inferred from direct assay	7543090	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of skin barrier	IEP IEP: Inferred from expression pattern	23403047	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	7543090	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cornified envelope	IDA IDA: Inferred from direct assay	7543090	GOA
located in keratohyalin granule	IDA IDA: Inferred from direct assay	1429717	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLG Protein Structure

S_100

Filaggrin

0
700
1400
2100
2800
3500
4061 a.a.

Protein Preferred Names	Protein Names
filaggrin	epidermal filaggrin

FLG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FLG	P20930	KLK5	Homo sapiens	Q9Y337	IF	23629652
Intra	FLG	P20930	KLK5	Homo sapiens	Q9Y337	EM	23629652
Intra	FLG	P20930	KLK5	Homo sapiens	Q9Y337	PLA	23629652

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FLG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71734	FLG Protein, Human (P.pastoris, His)	P20930 (D3838-E4061)	≥ 90%, as determined by reducing SDS-PAGE.

FLG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811096	Filaggrin Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89791	FLG/Filaggrin Antibody (YA9135)	WB, ICC/IF, IF-Tissue, IHC-P, IP	human

Related Diseases

Diseases	Alias
Dermatitis, Atopic, 2	Atopic Dermatitis 2 ATOD2 Dermatitis, Atopic, Susceptibility To, 2 Dermatitis, Atopic, 2, Susceptibility To Dermatitis, Atopic 2 Dermatitis Atopic 2 Atopic Eczema Dermatitis, Atopic, Type 2 Dermatitis, Atopic
Ichthyosis Vulgaris	Ichthyosis Simplex Dominant Congenital Ichthyosiform Erythroderma Common Ichthyosis Fish Scale Disease VI Ichthyoses Congenital Ichthyosis
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Paroxysmal Dystonia	Paroxysmal Dyskinesia Pxd - [Paroxysmal Dyskinesia]
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Cerebellar Hypoplasia/Atrophy, Epilepsy, And Global Developmental Delay	CHEGDD
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Keratosis	Actinic Keratosis Hyperkeratosis
Ichthyosis, X-Linked	X-Linked Ichthyosis Steroid Sulfatase Deficiency Placental Steroid Sulfatase Deficiency Steroid Sulfatase Deficiency Disease XLI Sts Deficiency Ssdd X-Linked Recessive Ichthyosis X-Linked Ichthyosis With Steryl-Sulphatase Deficiency X-Linked Placental Steryl-Sulphatase Deficiency Ssd X Linked Ichthyosis Recessive X-Linked Ichthyosis Rxli Syndromic Recessive X-Linked Ichthyosis Recessive X-Linked Ichthyosis With Extracutaneous Manifestations Syndromic Rxli X-Linked Ichthyosis Syndrome IXL Ichthyosis X-Linked Sex-Linked Ichthyosis X-Linked Ichthyosis With Steryl-Sulfatase Deficiency
Lichen Planus	Lichen Ruber Planus Lichen, Ruber Planus Ruber Planus Lp - [Lichen Planus] Lichen Planus Of Wilson Wilson Lichen Ruber
Ichthyosis, Congenital, Autosomal Recessive 4b	Harlequin Ichthyosis Autosomal Recessive Congenital Ichthyosis 4b Hi Harlequin Fetus ARCI4B Ichthyosis Congenita, Harlequin Fetus Type Harlequin Type Ichthyosis 'Harlequin Fetus' Harlequin Type Ichthyosis Congenita Harlequin Type Ichthyosis Fetalis Harlequin Baby Syndrome Ichthyosis Congenita, Harlequin Type Ichthyosis Fetalis, Harlequin Type Ichthyosis Congenita Harlequin Fetus Type Ichthyosis, Harlequin Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Irritant Dermatitis	Irritant Contact Dermatitis Primary Irritant Dermatitis Dermatitis, Irritant Contact Dermatitis, Irritant Irritant Contact Eczema Icd - [Irritant Contact Dermatitis] Irritant Contact Dermatitis, Unspecified Cause Non-Allergic Contact Dermatitis Irritant Contact Eczema Due To Wet Work Irritant Contact Dermatitis Due To Detergents Irritant Contact Eczema Due To Solvents Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants Irritant Contact Eczema Due To Cosmetics Or Emollients Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials Irritant Contact Eczema Due To Plants Or Other Vegetable Matter Irritant Contact Eczema Due To Foods Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids Irritant Contact Eczema Due To Saliva Irritant Contact Eczema Due To Incontinence Incontinence-Associated Dermatitis
Netherton Syndrome	NETH Ns Netherton Disease Comel-Netherton Syndrome Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige Bamboo Hair Syndrome Ichthyosis Linearis Circumflexa Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige Ilc Nts N Syndrome
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Epidermolysis Bullosa Dystrophica	Dystrophic Epidermolysis Bullosa Deb Dermolytic Epidermolysis Bullosa Epidermolysis Bullosa, Dermolytic Epidermolysis Bullosa, Dystrophic Epidermolysis Bullosa Dystrophic Dystrophic Eb - [Epidermolysis Bullosa]
Occupational Dermatitis	Dermatitis, Occupational Occupational Allergic Contact Dermatitis Occupational Eczema
Eczema Herpeticum	Herpes Simplex Dermatitis Herpes Simplex Eyelid Dermatitis Kaposi Varicelliform Eruption Herpes Simplex Dermatitis Of Eyelid Herpes Simplex Virus Dermatitis Herpes Simplex Virus Eyelid Dermatitis
Neurodermatitis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Epidermolysis Bullosa	Acantholysis Bullosa Eb
Legume Allergy	Fabaceae Allergy
Fruit Allergy	Allergy To Fruit
Dermatitis, Atopic, 4	ATOD4 Dermatitis, Atopic, Susceptibility To, 4 Atopic Dermatitis 4 Dermatitis, Atopic 4
Papilloma	Papillomatosis
Porokeratosis	Disseminated Superficial Actinic Porokeratosis Dsap Porokeratosis Of Mibelli Porokeratosis, Disseminated Superficial Actinic Porokeratosis, Disseminated Superficial Actinic, 1
Leukoplakia	Leukoplakia Of Gingiva Leukoplakia Of Oral Epithelium Leucoplakia Of Oral Mucosa Leukokeratosis Of Oral Mucosa
Esophagitis	Acute Esophagitis
Chicken Egg Allergy	Gallus Gallus Egg Allergy
Peanut Allergy	Allergy To Peanuts Peanut Allergic Reaction Allergies Peanut Peanut Hypersensitivity
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Psoriasis
Nut Allergy	Nut Allergic Reaction Nut Hypersensitivity Allergy To Nuts Allergy Nut
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Acne	Acne Vulgaris Acne Varioliformis Frontalis Acne
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Rhinitis	Runny Nose
Corticosteroid Allergy
Hypotrichosis
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Egg Allergy	Allergy To Eggs Allergies Egg Egg Hypersensitivity
Nasal Cavity Disease	Disorder Of Nasal Cavity
Seborrheic Dermatitis	Seborrhoeic Dermatitis Seborrhea Seborrhoeic Eczema Skin Seborrheic Dermatitis, Seborrheic
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Clear Cell Acanthoma	Acanthoma Pale Acanthoma Acanthoma, Clear Cell
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin
Metal Allergy
Alopecia
Alzheimer Disease 14	AD14 Alzheimer'S Disease 14 Alzheimer Disease-14 Alzheimer'S Disease 14, Late Onset
Mite Infestation	Mite Infestations Acariasis Infestation By Mites Nos
Photoallergic Dermatitis	Dermatitis, Photoallergic Photoallergic Contact Dermatitis Photoallergic Eczema Photo-Allergic Contact Eczema
Integumentary System Disease
Peeling Skin Syndrome	Deciduous Skin Familial Continuous Skin Peeling Syndrome Idiopathic Deciduous Skin Keratosis Exfoliativa Congenita Pss Peeling Skin Disease Skin Peeling Syndrome Familial Continuous Skin Peeling Keratolysis Exfoliativa Congenita Exfoliation Syndrome Keratolysis Exfoliativa
Cicatricial Lagophthalmos
Respiratory Allergy	Airway Allergy
Human Papillomavirus Infectious Disease	Hpv Papillomavirus Infections Human Papilloma Virus Infection
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Scabies	Sarcoptic Itch Infestation By Sarcoptes Scabiei Infestation By Sarcoptes Scabiei Var Hominis Infestation By Sarcoptes Scabiei Var. Hominis
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Seborrheic Infantile Dermatitis	Cradle Cap Infantile Seborrhoeic Dermatitis Seborrhoea Capitis Seborrhoeic Dermatitis Of Scalp Seborrhoeic Eczema Of Scalp Complement 5 Dysfunction Generalized Seborrheic Dermatitis Of Infants Infantile Seborrheic Dermatitis Pityriasis Capitis Seborrhea Capitis Seborrhea Sicca Dandruff Complement Component 5 Deficiency Seborrheic Dermatitis Seborrheic Dermatitis Of Scalp Scurfiness Of Scalp Seborrheic Dermatitis Of Infancy Infantile Seborrhoeic Eczema Neonatal Seborrhoeic Dermatitis Infantile Seborrhoeic Dermatitis Of The Scalp
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Sebaceous Gland Disease	Sebaceous Gland Anomaly Sebaceous Gland Diseases
Tinea Corporis	Dermatophytosis Of The Body Dermatophytosis Of The Trunk
Autoimmune Disease Of Skin And Connective Tissue
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Parasitic Ectoparasitic Infectious Disease	Ectoparasitic Infestations Ectoparasitism
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14844	Lagociclovir	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04911	FGFR1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04912	Fgfr1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-P10779	flg22Pst	Inhibitor	/	Unkown
HY-RS04975	FLG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04976	FLG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18589	Flg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25074	Flg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FLG	RGD	RGD:2620
Others	FLG	NCBI