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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Lagociclovir

HY-14844

(MIV-210)

Lagociclovir

Lagociclovir Chemical Structure

Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV.

Size Price Stock Quantity
5 mg $245 Backordered
10 mg $423 Backordered
50 mg Get quote
100 mg Get quote
Size Price Stock Quantity
5 mg €240 Backordered
10 mg €415 Backordered
50 mg Get quote
100 mg Get quote

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Inquiry Information
Product name: Lagociclovir
Cat. No.: HY-14844

Lagociclovir Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Lagociclovir

Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV.
IC50 value:
Target: Anti-HBV compound
Oral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA.
 

Chemical Information

M.Wt 269.23 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₁₀H₁₂FN₅O₃
CAS No 92562-88-4
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.7143 mL 18.5715 mL 37.1430 mL
5 mM 0.7429 mL 3.7143 mL 7.4286 mL
10 mM 0.3714 mL 1.8571 mL 3.7143 mL

References on Lagociclovir

Inhibitor Kit

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