1. Anti-infection
  2. HBV

Lagociclovir (Synonyms: MIV-210)

Cat. No.: HY-14844
Handling Instructions

Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV.

For research use only. We do not sell to patients.
Lagociclovir Chemical Structure

Lagociclovir Chemical Structure

CAS No. : 92562-88-4

Size Inquiry
5 mg Get quote for price and lead time
10 mg Get quote for price and lead time

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. IC50 value: Target: Anti-HBV compound Oral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.7143 mL 18.5715 mL 37.1430 mL
5 mM 0.7429 mL 3.7143 mL 7.4286 mL
10 mM 0.3714 mL 1.8571 mL 3.7143 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

269.23

Formula

C₁₀H₁₂FN₅O₃

CAS No.

92562-88-4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Lagociclovir
Cat. No.:
HY-14844
Quantity: