FLG/Filaggrin Antibody (YA9135)
(Synonyms: Filaggrin, FLG)
Based on 1 Customer Validation
FLG/Filaggrin Antibody (YA9135) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FLG/Filaggrin.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IHC-P, IP
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Reactivity :
human
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:50-500 | 1:50-500 | 1:100-500 | 1-2μg per 100-500μg Total protein |
Product Details
FLG/Filaggrin Antibody (YA9135) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FLG/Filaggrin.
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Host Mouse
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Species Reactivityhuman
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Calculated Molecular Weight Predicted band size: 447 kDa
OMIM: 603165
A synthesized peptide derived from human FLG/Filaggrin.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
FLG/Filaggrin is an Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis
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Subcellular Localization
Cytoplasmic granule
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Expression
Tissue_Specificity: Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland. In the skin, mainly expressed in stratum granulosum of the epidermis.
Induction: In cultured foreskin fibroblasts, up-regulated in response to Ca(2+) stimulation. -
Isoforms & Post-Translational Modification
FLG/Filaggrin has an amino acid length of 4061, molecular weight is 435170 Da.
Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate -
SwissProt ID
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Synonyms
Filaggrin, FLG
Documentation
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