ARL2BP - ADP ribosylation factor like GTPase 2 binding protein Gene

Also Known as BART; RP66; BART1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23568

About ARL2BP

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:57,245,259-57,253,635 (from NCBI)

This gene has 4 transcripts (splice variants), 228 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 36.7), fat (RPKM 27.6) and 25 other tissues.

Summary

ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]

ARL2BP Products (1)

mRNA	Protein	Name
NM_012106.4	NP_036238.1	ADP-ribosylation factor-like protein 2-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11847227	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	18234692	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in maintenance of protein location in nucleus	IMP IMP: Inferred from mutant phenotype	18234692	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	18234692	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	16525022	GOA
located in midbody	IDA IDA: Inferred from direct assay	16525022	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	11809823	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL2BP Protein Structure

ARL2_Bind_BART

0
100
163 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-like protein 2-binding protein	ADP-ribosylation factor like 2 binding protein

ARL2BP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARL2BP	Q9Y2Y0	CFAP20	Homo sapiens	Q9Y6A4	Anti Tag CoIP	33961781
Intra	ARL2BP	Q9Y2Y0	CFAP20	Homo sapiens	Q9Y6A4	Validated Y2H	32296183
Intra	ARL2BP	Q9Y2Y0	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	ARL2BP	Q9Y2Y0	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	ARL2BP	Q9Y2Y0	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	ARL2BP	Q9Y2Y0	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	ARL2BP	Q9Y2Y0	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	ARL2BP	Q9Y2Y0	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	ARL2BP	Q9Y2Y0	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ARL2BP	Q9Y2Y0	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ARL2BP	Q9Y2Y0	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ARL2BP	Q9Y2Y0	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	ARL2BP	Q9Y2Y0	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	ARL2BP	Q9Y2Y0	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	ARL2BP	Q9Y2Y0	ARL3	Homo sapiens	P36405	Y2H Prey Pooling	32296183
Intra	ARL2BP	Q9Y2Y0	ARL3	Homo sapiens	P36405	Y2H Array	32296183
Intra	ARL2BP	Q9Y2Y0	ARL3	Homo sapiens	P36405	Anti Tag CoIP	33961781
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Validated Y2H	27107012
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Array	32296183
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Anti Tag CoIP	33961781
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Pull Down	19368893
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Array	21988832
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	GMS	19368893
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	X-Ray Diffraction	19368893
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Prey Pooling	25416956
Intra	ARL2BP	Q9Y2Y0	ARL2	Homo sapiens	P36404	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARL2BP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71660	ARL2BP Protein, Human (GST)	Q9Y2Y0-1 (M1-H163)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76156	ARL2BP Protein, Human (His)	Q9Y2Y0-1 (M1-H163)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 82 With Or Without Situs Inversus	Retinitis Pigmentosa With Or Without Situs Inversus RP82 Retinitis Pigmentosa, With/Without Situs Inversus
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa 66	RP66 Retinitis Pigmentosa, Type 66
Ciliary Dyskinesia, Primary, 43	CILD43 Primary Ciliary Dyskinesia 43 Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa 74	RP74 Retinitis Pigmentosa, Type 74
Oral Hairy Leukoplakia	Hairy Leukoplakia Leukoplakia, Hairy Hairy Leucoplakia
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Keratinizing Squamous Cell Carcinoma	Squamous Cell Carcinoma, Keratinizing Keratinizing Epidermoid Carcinoma
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00986	ARL2BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21093	Arl2bp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27611	Arl2bp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARL2BP	VGNC	VGNC:104681
Mus musculus	ARL2BP	MGD	MGI:1349429
Bos taurus	ARL2BP	VGNC	VGNC:26142
Rattus norvegicus	ARL2BP	RGD	RGD:1561471
Canis familiaris	ARL2BP	VGNC	VGNC:38110
Others	ARL2BP	NCBI