Sigirr - single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Gene

Also Known as TIR8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24058

Summary

Involved in acute-phase response; negative regulation of chemokine production; and negative regulation of cytokine-mediated signaling pathway. Predicted to be located in membrane. Is expressed in genitourinary system. Orthologous to human SIGIRR (single Ig and TIR domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Sigirr Products (2)

mRNA Protein Name
NM_001355055.1 NP_001341984.1 single Ig IL-1-related receptor
NM_023059.3 NP_075546.2 single Ig IL-1-related receptor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IMP
IMP: Inferred from mutant phenotype
12925853 MGI
involved in negative regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
12925853 MGI
involved in negative regulation of cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12925853 MGI
involved in negative regulation of interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12925853 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

single Ig IL-1-related receptor

  • single Ig IL-1 receptor related protein

  • single Ig IL-1R-related molecule

  • single Ig IL-1R-related protein

  • single immunoglobulin domain-containing IL1R-related protein

  • toll/interleukin-1 receptor 8

Recombinant Sigirr Proteins

Cat. No. Product Name Accession Purity
HY-P74547 SIGIRR Protein, Mouse (HEK293, His) Q9JLZ8 (M1-H117) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12896 SIGIRR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18099 Sigirr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24573 Sigirr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sigirr NCBI NCBI:59307