SIGIRR - single Ig and TIR domain containing Gene

Also Known as TIR8; IL-1R8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59307

About SIGIRR

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:405,716-417,397 (from NCBI)

This gene has 22 transcripts (splice variants), 176 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues.

Summary

Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGIRR Products (3)

mRNA Protein Name
NM_001135053.2 NP_001128525.1 single Ig IL-1-related receptor
NM_001135054.2 NP_001128526.1 single Ig IL-1-related receptor
NM_021805.3 NP_068577.2 single Ig IL-1-related receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12925853 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Toll signaling pathway IMP
IMP: Inferred from mutant phenotype
12925853 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IMP
IMP: Inferred from mutant phenotype
10346978 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGIRR Protein Structure

TIR

TIR: TIR domain (167 - 303)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

single Ig IL-1-related receptor

  • single Ig IL-1R-related molecule

SIGIRR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIGIRR Q6IA17 PALM3 Homo sapiens A6NDB9
Y2H
21187075
Intra
SIGIRR Q6IA17 PALM3 Homo sapiens A6NDB9
Anti Tag CoIP
21187075
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGIRR Proteins

Cat. No. Product Name Accession Purity
HY-P76064 SIGIRR Protein, Human (HEK293, Fc) Q6IA17-1 (M1-H118) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P76065 SIGIRR Protein, Human (HEK293, His) Q6IA17-1 (M1-H118) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Progressive Myoclonus Epilepsy 8

  • Emp8

  • Pme Type 8

  • Progressive Myoclonic Epilepsy Due To Cers1 Deficiency

  • Progressive Myoclonus Epilepsy Type 8
Loeffler Syndrome

  • Loeffler'S Pneumonia

  • Loffler'S Syndrome

  • Simple Pulmonary Eosinophilia
Inflammatory Diarrhea
Chemical Colitis
Central Nervous System Tuberculosis

  • Intracranial Tuberculoma

  • Tuberculoma Of Brain

  • Tuberculosis Of Meninges And Central Nervous System

  • Tuberculous Abscess Of Brain

  • Tuberculoma, Intracranial

  • Tuberculosis, Central Nervous System
Perinatal Necrotizing Enterocolitis

  • Necrotizing Enterocolitis

  • Enterocolitis Necrotizing

  • Enterocolitis, Necrotizing

  • Necrotizing Enterocolitis In Fetus Or Newborn

  • Perinatal Necrotising Enterocolitis

  • Pseudomembranous Enterocolitis In Newborn

  • Nec
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12896 SIGIRR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18099 Sigirr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24573 Sigirr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SIGIRR VGNC VGNC:65140
Canis familiaris SIGIRR VGNC VGNC:46167
Mus musculus SIGIRR MGD MGI:1344402
Rattus norvegicus SIGIRR RGD RGD:1306732
Bos taurus SIGIRR VGNC VGNC:34616
Others SIGIRR NCBI