Alpi - alkaline phosphatase, intestinal Gene

Also Known as Alp1; S51097

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24197

Summary

Enables Alkaline Phosphatase activity; metal ion binding activity; and protein homodimerization activity. Involved in dephosphorylation. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPI (Alkaline Phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]

Alpi Products (1)

mRNA Protein Name
NM_022665.3 NP_073156.3 intestinal-type alkaline phosphatase 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alkaline phosphatase activity IDA
IDA: Inferred from direct assay
7744844 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
15885097 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24076154 RGD
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
24076154 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
15885097 RGD
Biological Process GO Annotation Evidence References Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
24076154 RGD
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7744844 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intestinal-type alkaline phosphatase 1

  • Alkaline phosphatase 1, intestinal, defined by SSR

  • IAP-1

  • IAP-I

  • intestinal alkaline phosphatase 1

  • intestinal alkaline phosphatase I IAP-I

Recombinant Alpi Proteins

Cat. No. Product Name Accession Purity
HY-P700395 Alkaline Phosphatase/ALPI Protein, Rat (HEK293, His) P15693 (V21-N511) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00628 ALPI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00633 ALPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21294 Alpi Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27813 Alpi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alpi NCBI NCBI:248