ALPI - alkaline phosphatase, intestinal Gene

Also Known as IAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 248

About ALPI

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,456,153-232,460,753 (from NCBI)

This gene has 2 transcripts (splice variants), 362 orthologues and 3 paralogues. Biased expression in duodenum (RPKM 85.5), small intestine (RPKM 83.4) and 1 other tissue.

Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal Alkaline Phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of Bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

ALPI Products (1)

mRNA Protein Name
NM_001631.5 NP_001622.2 intestinal-type alkaline phosphatase precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protease binding IPI
IPI: Inferred from physical interaction
18307834 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALPI Protein Structure

Alk_phosphatase

Alk_phosphatase: Alkaline phosphatase (52 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 528 a.a.
Protein Preferred Names Protein Names

intestinal-type alkaline phosphatase

  • Kasahara isozyme

ALPI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALPI P09923 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
ALPI P09923 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
ALPI P09923 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALPI Proteins

Cat. No. Product Name Accession Purity
HY-P71692 Alkaline Phosphatase/ALPI Protein, Human (His) P09923 (E26-C500) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72822 Alkaline Phosphatase/ALPI Protein, Human (HEK293, His) P09923 (V20-D503) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700394 Alkaline Phosphatase/ALPI Protein, Human (HEK293, N-His) P09923 (V20-D503) ≥ 95%, as determined by reducing SDS-PAGE.

ALPI Antibodies

Cat. No. Product Name Application Reactivity
HY-P810632 intestinal alkaline phosphatase Antibody (YA9894) WB Human, Mouse
HY-P810633 intestinal alkaline phosphatase Antibody (YA9895) IHC-P Human, Mouse, Rat
HY-P810634 intestinal alkaline phosphatase Antibody (YA9896) WB, IHC-P Human
HY-P81814 Intestinal Alkaline Phosphatase Antibody (YA1559) WB, IHC-P Human
HY-P84037 Intestinal Alkaline Phosphatase Antibody(YA3734) WB, FC, ELISA Human
HY-P84037A Intestinal Alkaline Phosphatase Antibody(YA3734)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Hypophosphatasia

  • Phosphoethanolaminuria

  • Childhood Hypophosphatasia

  • Deficiency Of Alkaline Phosphatase

  • Hypophospatasia, Childhood

  • Hypophosphatasia Mild

  • Phosphoethanol-Aminuria

  • Rathburn Disease

  • Hpp

  • Rathbun Disease

  • Hypophosphatasia, Childhood

  • Infantile Hypophosphatasia
Trachea Adenoid Cystic Carcinoma

  • Tracheal Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Trachea
Tracheal Cancer

  • Tracheal Carcinoma

  • Malignant Neoplasm Of Trachea

  • Tracheal Neoplasms

  • Pancoast Tumor

  • Pulmonary Sulcus Neoplasm

  • Pancoast Syndrome
Trachea Carcinoma

  • Pancoast Tumor

  • Carcinoma Of The Trachea

  • Pancoast'S Tumor

  • Malignant Superior Sulcus Tumor

  • Malignant Superior Sulcus Tumour

  • Pancoast Tumour

  • Pancoast'S Syndrome

  • Pancoast'S Tumour

  • Pulmonary Sulcus Tumor

  • Pulmonary Sulcus Tumour

  • Superior Pulmonary Sulcus Syndrome

  • Pancoast Syndrome
Testis Seminoma

  • Seminoma Of Testis

  • Seminoma Testis

  • Testicular Seminoma Pure

  • Seminoma
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00628 ALPI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00633 ALPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21294 Alpi Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27813 Alpi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ALPI RGD RGD:2099
Macaca mulatta ALPI VGNC VGNC:69800
Others ALPI NCBI