Fcgr4 - Fc receptor, IgG, low affinity IV Gene

Also Known as Fcrl3; CD16-2; FcgRIV; Fcgr3a; FcgammaRIV; 4833442P21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 246256

Summary

Enables IgE receptor activity and IgG receptor activity. Involved in neutrophil activation and positive regulation of bone resorption. Located in cell surface. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); hematologic Cancer (multiple); and immunodeficiency 20. Orthologous to human FCGR3A (Fc fragment of IgG receptor IIIa) and FCGR3B (Fc fragment of IgG receptor IIIb). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr4 Products (1)

mRNA Protein Name
NM_144559.2 NP_653142.2 low affinity immunoglobulin gamma Fc region receptor III-A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IgE receptor activity IDA
IDA: Inferred from direct assay
17558411 MGI
enables IgG receptor activity IDA
IDA: Inferred from direct assay
16039578 MGI
Biological Process GO Annotation Evidence References Source
involved in Fc receptor-mediated immune complex endocytosis IDA
IDA: Inferred from direct assay
28389502 MGI
involved in dendritic cell antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
28389502 MGI
involved in neutrophil activation IMP
IMP: Inferred from mutant phenotype
18097064 MGI
involved in positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
25824719 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
17558411 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
28389502 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low affinity immunoglobulin gamma Fc region receptor III-A

  • Fc fragment of IgG, low affinity IIIa, receptor for (CD16)

  • Fc fragment of IgG, low affinity III, receptor for (CD16)

  • Fc gammaRIV

  • Fc receptor-like 3

  • IgG Fc receptor III-A

  • low affinity immunoglobulin gamma Fc region receptor IV

Recombinant Fcgr4 Proteins

Cat. No. Product Name Accession Purity
HY-P76916 FcgR4/CD16-2 Protein, Mouse (HEK293, His-Avi) A0A0B4J1G0 (Q19-Q203) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76917 FcgR4/CD16-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) A0A0B4J1G0 (Q19-Q203) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76918 FcgR4/CD16-2 Protein, Mouse (HEK293, His) A0A0B4J1G0 (G21-Q203) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS24567 Fcgr3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown