FSHB - follicle stimulating hormone subunit beta Gene

Also Known as HH24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2488

About FSHB

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:30,231,014-30,235,194 (from NCBI)

This gene has 3 transcripts (splice variants), 140 orthologues, 9 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

FSHB Products (3)

mRNA	Protein	Name
NM_000510.4	NP_000501.1	follitropin subunit beta precursor
NM_001018080.3	NP_001018090.1	follitropin subunit beta precursor
NM_001382289.1	NP_001369218.1	follitropin subunit beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables follicle-stimulating hormone activity	IDA IDA: Inferred from direct assay	2494176	GOA
enables follicle-stimulating hormone activity	IMP IMP: Inferred from mutant phenotype	11514332	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11222739	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	24692546	GOA
involved in positive regulation of steroid biosynthetic process	IDA IDA: Inferred from direct assay	2494176	GOA
involved in regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	24692546	GOA
involved in transforming growth factor beta receptor signaling pathway	IEP IEP: Inferred from expression pattern	14557487	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14602737	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	2494176	GOA
part of follicle-stimulating hormone complex	IDA IDA: Inferred from direct assay	2494176	GOA
part of follicle-stimulating hormone complex	IPI IPI: Inferred from physical interaction	11222739	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FSHB Protein Structure

Cys_knot

0
100
129 a.a.

Protein Preferred Names	Protein Names
follitropin subunit beta	FSH-B

FSHB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FSHB	P01225	CGA	Homo sapiens	P01215	X-Ray Diffraction	22802634
Intra	FSHB	P01225	CGA	Homo sapiens	P01215	GMS	22802634
Intra	FSHB	P01225	CGA	Homo sapiens	P01215	X-Ray Diffraction	15662415

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FSHB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70237	FSH Protein, Human (HEK293, Flag-His)	P01215 (A25-S116)&P01225 (N19-E129)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70238	FSH beta Protein, Human (HEK293, His)	P01225 (N19-E129)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74133	FSH Protein, Human (HEK293, Fc)	P01215 (A25-S116)&P01225 (N19-E129)	≥ 95%, as determined by reducing SDS-PAGE.

FSHB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83903	FSHB Antibody (YA3600)	WB, FC, ELISA	Human
HY-P83903A	FSHB Antibody (YA3600)(PBS only)	WB, FC, ELISA	Human
HY-P86035	FSHB Antibody (YA5727)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia	Follicle-Stimulating Hormone Deficiency, Isolated Hypogonadotropic Hypogonadism 24 Without Anosmia HH24 Isolated Fsh Deficiency Isolated Follicle-Stimulating Hormone Deficiency Isolated Follicle-Stimulating Hormone Deficiency Isolated Follicle Stimulating Hormone Deficiency Hypogonadism, Hypogonadotropic, Type 24, Without Anosmia Isolated Follitropin Deficiency
Hypogonadism
Infertility
Amenorrhea	Absence Of Menstruation Amenia
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Ovarian Hyperstimulation Syndrome	OHSS Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous Secondary Meig'S Syndrome Ohss - [Ovarian Hyperstimulation Syndrome] Hyperstimulation Of Ovaries Nos Hyperstimulation Of Ovaries Associated With Induced Ovulation
Anovulation
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovarian Disease Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome	Wagr Syndrome 11p Partial Monosomy Syndrome Chromosome 11p13 Deletion Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome 11p Deletion Syndrome Chromosome 11p Deletion Syndrome Wagr Complex Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome Deletion 11p13 WAGR Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Chromosome 11p Deletion 11p Deletion 11p Monosomy Deletion 11p Monosomy 11p Partial Monosomy 11p Agr Triad Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome Wagr Contiguous Gene Syndrome Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome Del(11)(P13) Monosomy 11p13 Chromosome 11, Deletion 11p
Hypopituitarism	Pituitary Hypofunction Pituitary Insufficiency Pituitary Hormone Deficiency Subpituitarism Hypophyseal Dystrophy Hypohypophysism Anterior Pituitary Insufficiency Deficient Secretion Of One Or More Pituitary Hormones Hypopituitarism Syndrome Pituitary Deficiency Pituitary Failure Pituitary Insufficiency Nos Anterior Pituitary Hypofunction Deficient Secretion Of All Pituitary Hormones Hypopituitary Dwarfism Hyposomatotropic Dwarfism Hypophyseal Dwarfism Hypopituitary Cachexia Hypophyseal Short Stature Panhypopituitarism Syndrome Pituitary Cachexia Juvenile Hypopituitarism Pituitary Dwarfism Pituitary Gland Hypofunction Primary Hypopituitarism Secondary Hypogonadism Prepubertal Panhypopituitarism Prepubertal Dwarfism Postpartum Panhypopituitary Syndrome Postpartum Hypopituitarism Pituitary Short Stature Pituitary Infantilism Pituitary Hypogonadism Pituitary Hypoadrenocorticism
Neonatal Thyrotoxicosis
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Disorder Of Sexual Development	Disorder Of Sex Development Disorders Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Sex Differentiation Disorders
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05123	FSHB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19899	Fshb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26400	Fshb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FSHB	VGNC	VGNC:40996
Felis catus	FSHB	VGNC	VGNC:62378
Rattus norvegicus	FSHB	RGD	RGD:2630
Macaca mulatta	FSHB	VGNC	VGNC:101088
Mus musculus	FSHB	MGD	MGI:95582
Others	FSHB	NCBI