FZD2 - frizzled class receptor 2 Gene

Also Known as Fz2; fz-2; fzE2; hFz2; OMOD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2535

About FZD2

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,557,484-44,561,262 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues, 15 paralogues and is associated with 3 phenotypes.

Summary

This intronless gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

FZD2 Products (1)

mRNA	Protein	Name
NM_001466.4	NP_001457.1	frizzled-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	19388021	GOA
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	28733458	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25417160	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	29276006	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18215320	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18929644	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18215320	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19038973	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18929644	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD2 Protein Structure

Frizzled

0
100
200
300
400
500
565 a.a.

Protein Preferred Names	Protein Names
frizzled-2	frizzled 2, seven transmembrane spanning receptor

FZD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	FZD2	Q14332	tcdB	Clostridium difficile	M4NKV9	BLI	29748286
Cross	FZD2	Q14332	Fyn	Mus musculus	P39688	Peptide Array	25417160

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78722	FZD2 Protein, Human (HEK293, Fc)	Q14332 (Q24-P190)	≥ 95%, as determined by reducing SDS-PAGE.

FZD2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811188	Frizzled 2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Omodysplasia 2	OMOD2 Omodysplasia, Autosomal Dominant Autosomal Dominant Omodysplasia Omodysplasia Type 2 Omodysplasia, Type 2
Robinow Syndrome, Autosomal Dominant 2	Autosomal Dominant Robinow Syndrome 2 DRS2 Robinow, Autosomal Dominant Syndrome, Type 2
Robinow Syndrome, Autosomal Dominant 1	Autosomal Dominant Robinow Syndrome 1 DRS1 Robinow Dwarfism Fetal Face Syndrome Acral Dysostosis With Facial And Genital Abnormalities Robinow, Autosomal Dominant Syndrome, Type 1
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Autosomal Dominant Robinow Syndrome	Fetal Face Syndrome Robinow Syndrome, Autosomal Dominant
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Omodysplasia	Omodysplasia Type 1 Omodysplasia 2
Midface Hypoplasia, Hearing Impairment, Elliptocytosis, And Nephrocalcinosis	MFHIEN
Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly	Fuhrmann Syndrome Bowing Of The Femurs, Aplasia Or Hypoplasia Of The Fibula, And Digital Anomalies Fibular Hypoplasia Or Aplasia-Femoral Bowing-Oligodactyly Syndrome Fuhrmann-Rieger-De Sousa Syndrome FUHRS Fibular Aplasia Hypoplasia Femoral Bowing And Poly- Syn- And Oligodactyly
Omodysplasia 1	OMOD1 Autosomal Recessive Omodysplasia Omodysplasia Autosomal Recessive Omodysplasia Generalized Form Omodysplasia Type 1 Omodysplasia, Generalized Form Omodysplasia, Autosomal Recessive Micromelic Dysplasia, Congenital, With Dislocation Of Radius Micromelic Dysplasia Congenita With Dislocation Of Radius Micromelic Dysplasia-Dislocation Of Radius Syndrome Micromelic Dysplasia Congenital With Dislocation Of Radius Omodysplasia, Type 1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05178	FZD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18359	Fzd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24838	Fzd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FZD2	VGNC	VGNC:72834
Rattus norvegicus	FZD2	RGD	RGD:71012
Mus musculus	FZD2	MGD	MGI:1888513
Bos taurus	FZD2	VGNC	VGNC:29167
Felis catus	FZD2	VGNC	VGNC:62404
Canis familiaris	FZD2	VGNC	VGNC:41030
Others	FZD2	NCBI