2. Recombinant Proteins
  3. Receptor Proteins
  4. G-Protein-Coupled Receptors (GPCRs)
  5. Frizzled
  6. Frizzled-2

Frizzled-2

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Cat. No. Product Name / Synonyms Species Source
  • HY-P78722
    FZD2 Protein, Human (HEK293, Fc)

    FZD2; Frizzled-2; Fz-2; hFz2; FzE2

    		Human HEK293
    FZD2 Protein, a receptor for Wnt proteins, activates the beta-catenin canonical pathway, inhibiting GSK-3 kinase and triggering Wnt target genes. FZD2 and some family members have a secondary PKC-calcium pathway, yet its integration with the canonical pathway remains unclear. PKC seems crucial for Wnt-mediated GSK-3 kinase inactivation. These pathways may involve G-protein interactions, contributing to polarity information transmission during tissue morphogenesis. Notably, FZD2 acts as a receptor for C. difficile toxin TcdB in the colonic epithelium, occupying the Wnt-adducted palmitoleate binding site, preventing downstream Wnt signaling. FZD2 Protein, Human (HEK293, Fc) is the recombinant human-derived FZD2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of FZD2 Protein, Human (HEK293, Fc) is 167 a.a., with molecular weight of 50-62 kDa.
  • HY-P70918
    FZD2 Protein, Mouse (HEK293, Fc)

    Frizzled-2; Fz-2; mFz2; Fzd2; frizzled (Drosophila) homolog 2

    		Mouse HEK293
    FZD2 is a Wnt receptor that primarily activates the β-catenin classical pathway, involving disheveled protein, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene activation. Although some family members exhibit second PKC and calcium flux pathways, the precise differentiation and integration with the canonical pathways remains unclear. FZD2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FZD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FZD2 Protein, Mouse (HEK293, Fc) is 140 a.a., with molecular weight of 55-60 kDa.
Cat. No. Product Name Effect Purity