Frizzled-2
Encoded by the FZD2 gene, Frizzled-2 is a Wnt receptor whose cysteine-rich domain engages ligands such as Wnt5a and Wnt7b. Compared with Frizzled-1, it is more often coupled to non-canonical branches of Wnt signaling, including planar cell polarity and Wnt/Ca2+ cascades that act through Dishevelled and downstream JNK or PKC. Fzd2-null mice display congenital heart defects, pointing to a role in cardiac morphogenesis, and the receptor is also expressed in chondrocytes, vasculature and multiple epithelia. Elevated FZD2 expression has been reported in colorectal, ovarian and liver tumors, where it is linked to invasiveness, making it a candidate biomarker and a target for Wnt-pathway modulators.
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Frizzled-2 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
