GFRA1 - Gfra1 GDNF family receptor alpha 1 Gene
Species: Rattus norvegicus
Summary
Enables Integrin binding activity and neurotrophin receptor activity. Involved in several processes, including male gonad development; neuron projection development; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Part of plasma membrane protein complex and receptor complex. Used to study Parkinsonism. Biomarker of Parkinsonism; brain ischemia; and sciatic neuropathy. Orthologous to human GFRA1 (GDNF family receptor alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
GFRA1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_012959.2 | NP_037091.1 | GDNF family receptor alpha-1 precursor |
| Molecular Function GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| enables glial cell-derived neurotrophic factor receptor activity |
IDA
IDA: Inferred from direct assay
|
25242331 | RGD |
| enables integrin binding |
IPI
IPI: Inferred from physical interaction
|
18465789 | RGD |
| enables neurotrophin receptor activity |
IDA
IDA: Inferred from direct assay
|
8674117 | RGD |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10545102 | RGD |
| Biological Process GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| involved in cell migration |
IMP
IMP: Inferred from mutant phenotype
|
16906542 | RGD |
| involved in glial cell-derived neurotrophic factor receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
25242331 | RGD |
| involved in kidney development |
IEP
IEP: Inferred from expression pattern
|
15381258 | RGD |
| involved in male gonad development |
IEP
IEP: Inferred from expression pattern
|
22111653 | RGD |
| involved in neuron differentiation |
IMP
IMP: Inferred from mutant phenotype
|
21865882 | RGD |
| involved in neuron projection development |
IDA
IDA: Inferred from direct assay
|
15381258 | RGD |
| involved in positive regulation of peptidyl-tyrosine phosphorylation |
IDA
IDA: Inferred from direct assay
|
10545102 | RGD |
| Cellular Component GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| located in axon |
IDA
IDA: Inferred from direct assay
|
16841166 | RGD |
| located in external side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
16086681 | RGD |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
16086681 | RGD |
| located in neuronal cell body |
IDA
IDA: Inferred from direct assay
|
16841166 | RGD |
| part of plasma membrane protein complex |
IDA
IDA: Inferred from direct assay
|
10545102 | RGD |
| part of receptor complex |
IDA
IDA: Inferred from direct assay
|
15709767 | RGD |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
GDNF family receptor alpha-1 |
|
|
GFRA1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Referencias |
|---|---|---|---|---|---|---|---|
|
Cross
|
Gfra1 | Q62997 | SORL1 | Homo sapiens | Q92673 | 23333276 |
Recombinant GFRA1 Proteins
| Referencia número | Nombre del producto | Accession | Pureza |
|---|---|---|---|
| HY-P76948 | GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc) | Q62997-1 (D25-L445) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P76949 | GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His) | Q62997-1 (D25-L445) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Referencia número | Nombre del producto |
Efecto
|
Pureza |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS05386 | GFRA1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS18390 | Gfra1 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS24871 | Gfra1 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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