Gss - glutathione synthetase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25458

Summary

Enables anion binding activity; glutathione synthase activity; and identical protein binding activity. Involved in several processes, including glutathione biosynthetic process; response to amino acid; and response to tumor necrosis factor. Located in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and hemolytic anemia due to glutathione synthetase deficiency. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Gss Products (1)

mRNA Protein Name
NM_012962.1 NP_037094.1 glutathione synthetase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10964706 RGD
enables glutathione binding IDA
IDA: Inferred from direct assay
10964706 RGD
enables glutathione synthase activity IDA
IDA: Inferred from direct assay
7862666 RGD
enables glycine binding IDA
IDA: Inferred from direct assay
10964706 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
7862666 RGD
enables peptide binding IPI
IPI: Inferred from physical interaction
10964706 RGD
Biological Process GO Annotation Evidence References Source
involved in glutathione biosynthetic process IDA
IDA: Inferred from direct assay
10964706 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
19212806 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19212806 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
16011481 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18653662 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutathione synthetase

  • GSH synthetase

  • GSH-S

  • glutathione synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113306 1-Methyladenine 99.99% Unkown
HY-W015600 2-Acetamidophenol 99.73% Unkown
HY-W015600S 2-Acetamidophenol-d3 99.48% Unkown
HY-RS05871 GSS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11188 PRNP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17796 Gss Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24264 Gss Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gss NCBI NCBI:2937