1-Methyladenine

Cat. No.: HY-113306 Purity: 98.49%: FAQs
Data Sheet SDS COA Handling Instructions

1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

For research use only. We do not sell to patients.

1-Methyladenine Chemical Structure

CAS No. : 5142-22-3

Size	Price	Stock
5 mg	USD 120	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Biological Activity
Purity & Documentation
References
Customer Review

Description

1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

149.15

Appearance

Solid

Formula

C₆H₇N₅

CAS No.

5142-22-3

SMILES

NC1=C2N=CN=C2N=CN1C

Structure Classification

Others

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 5.2 mg/mL (34.86 mM; ultrasonic and warming and heat to 80°C)

DMSO : 5 mg/mL (33.52 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7047 mL	33.5233 mL	67.0466 mL
5 mM	1.3409 mL	6.7047 mL	13.4093 mL
10 mM	0.6705 mL	3.3523 mL	6.7047 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 1.39 mg/mL (9.32 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1.39 mg/mL (9.32 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 1.39 mg/mL (9.32 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 98.49%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (253 KB) HNMR (215 KB) LCMS (118 KB)

Handling Instructions (2659 KB)

References

[1]. Falnes PØ, et al. Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Res. 2004 Dec 1;32(21):6260-7. Print 2004. [Content Brief]

[2]. Yang H, et al. Effect of 1-methyladenine on double-helical DNA structures. FEBS Lett. 2008 May 14;582(11):1629-33. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

1-Methyladenine5142-22-3Endogenous MetaboliteInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email address *

Phone number *

Organization name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name			Lot #
Applicant Name *			Email address *
Phone number			Department *
Organization name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

1-Methyladenine

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator