5142-22-3
5142-22-3
Chemical Structure
1-Methyladenine
- CAS No.: 5142-22-3
- Formula:C6H7N5
- Molecular Weight:149.15
IUPAC Name: 1-methyl-1H-purin-6-amine
InChIKey: HPZMWTNATZPBIH-UHFFFAOYSA-N
SMILES: NC1=C2N=CN=C2N=CN1C
Biological Activity: 1-Methyladenine is a gonad maturation-promoting regulator. 1-Methyladenine is produced in testes and ovarian follicle cells of starfish under the induction of gonad-stimulating substance (GSS). 1-Methyladenine promotes starfish oocyte maturation and spawning, and modifies bases that regulate DNA structure. 1-Methyladenine converts T-A base pairs in double-stranded DNA into non-disruptive T (anti)m1A (syn) Hoogsteen conformation. If this conformational base is not repaired in a timely manner, 1-Methyladenine transforms into cytotoxic DNA damage and blocks the replication process[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-Methyladenine | 99.99% | 1-Methyladenine is a gonad maturation-promoting regulator. 1-Methyladenine is produced in testes and ovarian follicle cells of starfish under the induction of gonad-stimulating substance (GSS). 1-Methyladenine promotes starfish oocyte maturation and spawning, and modifies bases that regulate DNA structure. 1-Methyladenine converts T-A base pairs in double-stranded DNA into non-disruptive T (anti)m1A (syn) Hoogsteen conformation. If this conformational base is not repaired in a timely manner, 1-Methyladenine transforms into cytotoxic DNA damage and blocks the replication process. | ||||||||||||||||||||
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9-Propenyladenine | 96.69% | 9-Propenyladenine (Mutagenic impurity of tenofovir disoproxil) is a purine derivative mutagenic impurity of Tenofovir Disoproxil (HY-13782A), and also serves as a capping group intermediate in the synthesis of N-substituted purines. | ||||||||||||||||||||
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(Z)-9-Propenyladenine | 97.21% | (Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. | ||||||||||||||||||||
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7-Methyladenine | 98.13% | 7-Methyladenine (N7-Methyladenine), a methylated analog of Adenine (HY-B0152), is a biomarker of DNA damage from exposure to methylating agents. | ||||||||||||||||||||
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9-Ethyladenine (Standard) | ≥98% | 9-Ethyladenine (Standard) is the analytical standard of 9-Ethyladenine (HY-119413). This product is intended for research and analytical applications. 9-Ethyladenine is a precursor of competitive antagonists of adenosine receptors (A1, A2, A3), with no significant inhibitory effect on adenine phosphoribosyltransferase (APRT). 9-Ethyladenine derivatives have high affinity and selectivity for A1 (Ki=27 nM), A2A (Ki=46 nM), and A3 (Ki=86 nM) receptors. 9-Ethyladenine does not inhibit brain APRT activity, can be used in the study of adenosine receptor-related diseases (such as nervous system diseases) models. | ||||||||||||||||||||
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3-Methyladenine (Standard) | ≥98% | 3-Methyladenine (Standard) is the analytical standard of 3-Methyladenine. This product is intended for research and analytical applications. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K. | ||||||||||||||||||||
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3-Methyladenine-d3 | 98.98% | 3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K. | ||||||||||||||||||||
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Adenine | 99.99% | Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis. | ||||||||||||||||||||
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Adenine-13C | 99.06% | Adenine-13C is the 13C labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis. | ||||||||||||||||||||
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Adenine monohydrochloride hemihydrate | 99.87% | Adenine (6-Aminopurine) monohydrochloride hemihydrate, a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine monohydrochloride hemihydrate acts as a chemical component of DNA and RNA. Adenine monohydrochloride hemihydrate also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis. | ||||||||||||||||||||
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Tenofovir impurity 12 | Tenofovir impurity 12 is an impurity of Tenofovir. | |||||||||||||||||||||
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