Gckr - glucokinase regulator Gene

Also Known as GKRP; GLRE

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25658

Summary

Enables several functions, including carbohydrate binding activity; enzyme binding activity; and enzyme inhibitor activity. Involved in negative regulation of Glucokinase activity; protein import into nucleus; and response to fructose. Located in cytosol; mitochondrion; and nucleoplasm. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (Glucokinase regulator). [provided by Alliance of Genome Resources, Apr 2022]

Gckr Products (1)

mRNA Protein Name
NM_013120.2 NP_037252.1 glucokinase regulatory protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbohydrate binding IDA
IDA: Inferred from direct assay
14627435 RGD
enables carbohydrate binding IMP
IMP: Inferred from mutant phenotype
11756407 RGD
enables enzyme binding IMP
IMP: Inferred from mutant phenotype
11756407 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
16186382 RGD
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
11756407 RGD
enables glucose sensor activity IDA
IDA: Inferred from direct assay
14627435 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
19807849 RGD
enables kinase inhibitor activity IDA
IDA: Inferred from direct assay
14627435 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10601273 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
16186382 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of hexokinase activity IDA
IDA: Inferred from direct assay
14627435 RGD
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
10601273 RGD
involved in response to fructose IDA
IDA: Inferred from direct assay
14627435 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
14627435 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10518020 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
10518020 RGD
located in nucleus IDA
IDA: Inferred from direct assay
10601273 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucokinase regulatory protein

  • 68-kDa regulatory protein

  • glucokinase (hexokinase 4) regulator

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05332 GCKR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08083 MAP4K5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08084 Map4k5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19603 Gckr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26099 Gckr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gckr NCBI NCBI:2646