IL37 - interleukin 37 Gene

Also Known as FIL1; FIL1Z; IL-1H; IL-23; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27178

About IL37

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,911,165-112,918,882 (from NCBI)

This gene has 5 transcripts (splice variants), 177 orthologues, 7 paralogues and is associated with 1 phenotype. Restricted expression toward skin (RPKM 8.8).

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight Other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL37 Products (5)

mRNA	Protein	Name
NM_014439.4	NP_055254.2	interleukin-37 isoform 1
NM_173202.2	NP_775294.1	interleukin-37 isoform 2
NM_173203.2	NP_775295.1	interleukin-37 isoform 3
NM_173204.2	NP_775296.1	interleukin-37 isoform 4
NM_173205.2	NP_775297.1	interleukin-37 isoform 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	30362558	GOA
acts upstream of negative regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	30362558	GOA
acts upstream of or within negative regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	30362558	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	33674380	GOA
acts upstream of or within regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	30362558	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL37 Protein Structure

IL1

0
100
200
218 a.a.

Protein Preferred Names	Protein Names
interleukin-37	FIL1 zeta

IL37 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL37	Q9NZH6	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	IL37	Q9NZH6	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	IL37	Q9NZH6	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	IL37	Q9NZH6	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	IL37	Q9NZH6	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	IL37	Q9NZH6	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	IL37	Q9NZH6	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	IL37	Q9NZH6	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	IL37	Q9NZH6	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	IL37	Q9NZH6	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	IL37	Q9NZH6	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	IL37	Q9NZH6	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	IL37	Q9NZH6	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	IL37	Q9NZH6	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	IL37	Q9NZH6	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL37 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70455	IL-37 Protein, Human	Q9NZH6-1 (K53-D218)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700128AF	Animal-Free IL-37 Protein, Human (His)	Q9NZH6-1 (K53-D218)	≥ 95%, as determined by reducing SDS-PAGE.

IL37 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89755	IL-1F7 Antibody (YA9099)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 31, Autosomal Recessive	IBD31 Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive Inflammatory Bowel Disease 31 Inflammatory Bowel Disease 31, Autosomal Recessive
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Colitis
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Eumycotic Mycetoma	Eumycetoma Maduromycosis Mycetoma Madura Foot Maduromycosis, Mycotic Mycotic Mycetoma Mycetoma Of Foot Eumycotic Maduromycosis Mycetoma Due To Fungal Infection
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Dermatomycosis	Dermatomycoses
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06763	IL37 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown