C5AR2 - complement C5a receptor 2 Gene

Homo sapiens

Also known as C5L2; GPF77; GPR77

Gene ID: 27202 | Gene type: protein coding

About C5AR2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,332,175-47,347,329 (from NCBI)

This gene has 2 transcripts (splice variants), 152 orthologues and 8 paralogues. Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues.

Summary

This gene encodes a G-protein coupled receptor 1 family member involved in the Complement System of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

C5AR2 Products(3)

mRNA	Protein	Name
NM_001271749.2	NP_001258678.1	C5a anaphylatoxin chemotactic receptor 2
NM_001271750.2	NP_001258679.1	C5a anaphylatoxin chemotactic receptor 2
NM_018485.3	NP_060955.1	C5a anaphylatoxin chemotactic receptor 2

C5AR2 Protein Structure

7tm_1

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

C5a anaphylatoxin chemotactic receptor 2

C5a anaphylatoxin chemotactic receptor C5L2

Related Diseases

Diseases

Alias

Complement Component 5 Deficiency

C5 Deficiency

C5D

Complement Component 3 Deficiency

C3 Deficiency

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01751	C5AR2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	C5AR2	VGNC	VGNC:70690
Bos taurus	C5AR2	VGNC	VGNC:26642
Rattus norvegicus	C5AR2	RGD	RGD:1303027
Canis familiaris	C5AR2	VGNC	VGNC:38597
Mus musculus	C5AR2	MGD	MGI:2442013
Others	C5AR2	NCBI

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