UBE2T - ubiquitin conjugating enzyme E2 T Gene

Also Known as FANCT; PIG50; HSPC150

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29089

About UBE2T

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,331,657-202,341,936 (from NCBI)

This gene has 12 transcripts (splice variants), 196 orthologues, 24 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 10.4), bone marrow (RPKM 10.2) and 22 other tissues.

Summary

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

UBE2T Products (2)

mRNA Protein Name
NM_001310326.2 NP_001297255.1 ubiquitin-conjugating enzyme E2 T isoform 2
NM_014176.4 NP_054895.1 ubiquitin-conjugating enzyme E2 T isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
17938197 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24389026 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
19589784 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16916645 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16916645 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
16916645 GOA
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
16916645 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K27-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K29-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
16916645 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
16916645 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2T Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (6 - 146)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 T

  • E2 ubiquitin-conjugating enzyme T

UBE2T Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2T Q9NPD8 FANCL Homo sapiens Q9NW38-1
Comig Non-Denat Gel
24389026
Intra
UBE2T Q9NPD8 FANCL Homo sapiens Q9NW38-1
GMS
24389026
Intra
UBE2T Q9NPD8 GNB2 Homo sapiens P62879
Validated Y2H
32814053
Intra
UBE2T Q9NPD8 GNB2 Homo sapiens P62879
Y2H Array
32814053
Intra
UBE2T Q9NPD8 GNB2 Homo sapiens P62879
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2T Proteins

Cat. No. Product Name Accession Purity
HY-P71409 UBE2T Protein, Human (His) Q9NPD8 (M1-V197) ≥ 95%, as determined by reducing SDS-PAGE.

UBE2T Antibodies

Cat. No. Product Name Application Reactivity
HY-P87128 UBE2T Antibody (YA6821) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group T

  • Fanconi Anemia Complementation Group T

  • FANCT
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Fanconi Anemia, Complementation Group R

  • Fanconi Anemia Complementation Group R

  • FANCR
Fanconi Anemia, Complementation Group Q

  • Fanconi Anemia Complementation Group Q

  • FANCQ
Fanconi Anemia, Complementation Group I

  • Fanconi Anemia Complementation Group I

  • FANCI
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Fanconi Anemia, Complementation Group D2

  • Fanconi Anemia Complementation Group D2

  • FANCD2

  • Fad2

  • Fa4

  • Fancd

  • Fanconi Pancytopenia Type 4

  • Fanconi Anemia, Complementation Group D

  • Fanconi Pancytopenia, Type 4

  • Facd

  • Fanconi Anemia Complementation Group D
Aplastic Anemia

  • Aplastic Anemia, Susceptibility To

  • Anemia Aplastic

  • Idiopathic Aplastic Anemia

  • Secondary Aplastic Anemia

  • Idiopathic Bone Marrow Failure

  • Aplastic Anemia Idiopathic

  • AA

  • Anemia, Aplastic

  • Aplastic Anemia, Idiopathic

  • Erythroid Aplasia

  • Aa - [Aplastic Anaemia]

  • Haematopoietic Aplasia

  • Aleukia Haemorrhagica

  • Anaemia Due To Decreased Red Cell Production

  • Aplasia Bone Marrow

  • Aplastic Bone Marrow

  • Hypoplastic Anaemia Nos

  • Myeloid Bone Marrow Aplasia

  • Pancytopenia

  • Panhaematopenia

  • Hypoproliferative Anaemia

  • Medullary Hypoplasia

  • Red Blood Cells Hypoplastic Anaemia

  • Panmyelophthisis

  • Panhemocytopenia

  • Refractive Hypoproliferative Anaemia

  • Toxic Anaemia

  • Toxic Aplastic Anaemia

  • Aplastic Anaemia Due To Toxic Cause

  • Idiopathic Aplastic Anaemia Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus UBE2T VGNC VGNC:36596
Macaca mulatta UBE2T VGNC VGNC:79467
Felis catus UBE2T VGNC VGNC:66765
Mus musculus UBE2T MGD MGI:1914446
Canis familiaris UBE2T VGNC VGNC:48066
Rattus norvegicus UBE2T RGD RGD:1310816
Others UBE2T NCBI