UBE2T - ubiquitin conjugating enzyme E2 T Gene

Homo sapiens

Also known as FANCT; PIG50; HSPC150

Gene ID: 29089 | Gene type: protein coding

About UBE2T

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,331,657-202,341,936 (from NCBI)

This gene has 12 transcripts (splice variants), 196 orthologues, 24 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 10.4), bone marrow (RPKM 10.2) and 22 other tissues.

Summary

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

UBE2T Products(2)

mRNA	Protein	Name
NM_001310326.2	NP_001297255.1	ubiquitin-conjugating enzyme E2 T isoform 2
NM_014176.4	NP_054895.1	ubiquitin-conjugating enzyme E2 T isoform 1

UBE2T Protein Structure

UQ_con

0
100
197 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 T

E2 ubiquitin-conjugating enzyme T

Recombinant UBE2T Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71409	UBE2T Protein, Human (His)	Q9NPD8 (M1-V197)	≥95%

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group T

Fanconi Anemia Complementation Group T

FANCT

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Fanconi Anemia, Complementation Group R

Fanconi Anemia Complementation Group R

FANCR

Fanconi Anemia, Complementation Group Q

Fanconi Anemia Complementation Group Q

FANCQ

Fanconi Anemia, Complementation Group I

Fanconi Anemia Complementation Group I

FANCI

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2	FANCD2
Fad2	Fa4
Fancd	Fanconi Pancytopenia Type 4
Fanconi Anemia, Complementation Group D	Fanconi Pancytopenia, Type 4
Facd	Fanconi Anemia Complementation Group D

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141891	M435-1279	Inhibitor	98.43%	Unkown
HY-126539	UBE2T/FANCL-IN-1		99.83%	Unkown
HY-RS15362	UBE2T Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBE2T	VGNC	VGNC:36596
Macaca mulatta	UBE2T	VGNC	VGNC:79467
Felis catus	UBE2T	VGNC	VGNC:66765
Mus musculus	UBE2T	MGD	MGI:1914446
Canis familiaris	UBE2T	VGNC	VGNC:48066
Rattus norvegicus	UBE2T	RGD	RGD:1310816
Others	UBE2T	NCBI

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