TGFBR1 - transforming growth factor, beta receptor 1 Gene

Also Known as Alk5; Skr4; Tgfr-1; tbetaR-I

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29591

About TGFBR1

Primary_assembly 5: 61,653,233-61,710,777 forward strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 236 orthologues, 11 paralogues and is associated with 40 phenotypes. Biased expression in Kidney (RPKM 195.8), Thymus (RPKM 187.5) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including embryo implantation; regulation of pri-miRNA transcription by RNA polymerase II; and response to prostaglandin E. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of protein-containing complex. Used to study leiomyoma; osteochondrodysplasia; and pulmonary hypertension. Biomarker of kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder Cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

TGFBR1 Products (1)

mRNA Protein Name
NM_012775.2 NP_036907.2 TGF-beta receptor type-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
17505012 RGD
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
8272871 RGD
enables protein-containing complex binding IMP
IMP: Inferred from mutant phenotype
8272871 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16617054 RGD
enables transforming growth factor beta binding IDA
IDA: Inferred from direct assay
8272871 RGD
enables transforming growth factor beta receptor activity, type I IMP
IMP: Inferred from mutant phenotype
8272871 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17347560 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
9699514 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
12815632 RGD
involved in embryo implantation IEP
IEP: Inferred from expression pattern
16426643 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
10835329 RGD
involved in negative regulation of endothelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17450384 RGD
involved in negative regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
21704009 RGD
involved in positive regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
21704009 RGD
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
8272871 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17505012 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
16682418 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
12097811 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
18760335 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12890451 RGD
involved in response to prostaglandin E IEP
IEP: Inferred from expression pattern
12890451 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
16682418 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8272871 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10590020 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10590020 RGD
located in caveola IDA
IDA: Inferred from direct assay
17878231 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
17878231 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16617054 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFBR1 Protein Structure

Activin_recp

Activin_recp: pfam01064 (29 - 103)

TGF_beta_GS

TGF_beta_GS: pfam08515 (173 - 200)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (206 - 493)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

TGF-beta receptor type-1

  • TGF-beta receptor type I

  • TGF-beta receptor type-1-like

  • TGF-beta type I receptor

  • activin receptor-like kinase 5

  • serine/threonine-protein kinase receptor R4

  • transforming growth factor, beta receptor I

  • transforming growth factor-beta receptor type I

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136244 PF-06952229 Inhibitor 99.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164793 TGFBR1-IN-2 / Unkown
HY-122856 AZ12601011 Inhibitor 99.78% Unkown
HY-N7694 Isotoosendanin 99.51% Unkown
HY-123900 AZ12799734 Inhibitor 98.67% Unkown
HY-RS14444 TGFBR1 Human Pre-designed siRNA Set A / Unkown
HY-RS14445 Tgfbr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14446 TGFBR1 Rat Pre-designed siRNA Set A / Unkown
HY-174531 Human TGFBR1 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TGFBR1 NCBI NCBI:7046