2. Gene
  3. TGFBR1 - transforming growth factor, beta receptor 1 Gene

TGFBR1 - transforming growth factor, beta receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Alk5; Skr4; Tgfr-1; tbetaR-I

Gene ID: 29591 | Gene type: protein coding

About TGFBR1

Primary_assembly 5: 61,653,233-61,710,777 forward strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 236 orthologues, 11 paralogues and is associated with 40 phenotypes. Biased expression in Kidney (RPKM 195.8), Thymus (RPKM 187.5) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including embryo implantation; regulation of pri-miRNA transcription by RNA polymerase II; and response to prostaglandin E. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of protein-containing complex. Used to study leiomyoma; osteochondrodysplasia; and pulmonary hypertension. Biomarker of kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder Cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

TGFBR1 Products(1)

mRNA Protein Name
NM_012775.2 NP_036907.2 TGF-beta receptor type-1 precursor

TGFBR1 Protein Structure

Activin_recp

Activin_recp: pfam01064 (29 - 103)

TGF_beta_GS

TGF_beta_GS: pfam08515 (173 - 200)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (206 - 493)

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  • 501 a.a.
Protein Preferred Names Protein Names

TGF-beta receptor type-1

TGF-beta receptor type I

TGF-beta receptor type-1-like

TGF-beta type I receptor

activin receptor-like kinase 5

serine/threonine-protein kinase receptor R4

transforming growth factor, beta receptor I

transforming growth factor-beta receptor type I

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136244 PF-06952229 Inhibitor 99.92% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122856 AZ12601011 Inhibitor 99.88% Unkown
HY-123900 AZ12799734 Inhibitor 98.07% Unkown
HY-129171 TGFBR1-IN-1 Inhibitor / Unkown
HY-RS14444 TGFBR1 Human Pre-designed siRNA Set A / Unkown
HY-RS14445 Tgfbr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14446 TGFBR1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TGFBR1 NCBI NCBI:7046
Mus musculus TGFBR1 NCBI NCBI:21812