Sirt7 - sirtuin 7 Gene
Species: Rattus norvegicus
About Sirt7
This gene has 2 transcripts (splice variants), 189 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 16.5), Spleen (RPKM 93.4) and 9 other tissues.
Summary
Predicted to enable several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein-propionyllysine depropionylase activity; and transcription corepressor activity. Predicted to be involved in several processes, including cellular macromolecule biosynthetic process; protein deacylation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear speck; nucleolus organizer region; and site of double-strand break. Predicted to be active in nucleus. Orthologous to human SIRT7 (Sirtuin 7). [provided by Alliance of Genome Resources, Apr 2022]
Sirt7 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001107073.1 | NP_001100543.1 | NAD-dependent protein deacetylase sirtuin-7 |
Sirt7 Protein Structure
Smc: cl34174 (7 - 100)
SIRT7: cd01410 (101 - 338)
- 0
- 100
- 200
- 300
- 400
- 426 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NAD-dependent protein deacetylase sirtuin-7 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-135899 | SIRT7 inhibitor 97491 | Inhibitor | 98.81% | Unkown |
| HY-159124 | YZL-51N | Inhibitor | 95.0% | Unkown |
| HY-150727 | SIRT5 inhibitor 4 | Inhibitor | 98.37% | Unkown |
| HY-156489 | Epigenetic factor-IN-1 | Inhibitor | / | Unkown |
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