2. Gene
  3. Sirt7 - sirtuin 7 Gene

Sirt7 - sirtuin 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 303745 | Gene type: protein coding

About Sirt7

Primary_assembly 10: 105,896,476-105,903,172 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 189 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 16.5), Spleen (RPKM 93.4) and 9 other tissues.

Summary

Predicted to enable several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein-propionyllysine depropionylase activity; and transcription corepressor activity. Predicted to be involved in several processes, including cellular macromolecule biosynthetic process; protein deacylation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear speck; nucleolus organizer region; and site of double-strand break. Predicted to be active in nucleus. Orthologous to human SIRT7 (Sirtuin 7). [provided by Alliance of Genome Resources, Apr 2022]

Sirt7 Products(1)

mRNA Protein Name
NM_001107073.1 NP_001100543.1 NAD-dependent protein deacetylase sirtuin-7

Sirt7 Protein Structure

Smc

Smc: cl34174 (7 - 100)

SIRT7

SIRT7: cd01410 (101 - 338)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-7

NAD-dependent deacetylase sirtuin-7

NAD-dependent protein deacylase sirtuin-7

SIR2-like protein 7

regulatory protein SIR2 homolog 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135899 SIRT7 inhibitor 97491 Inhibitor 98.03% Unkown
HY-155353 ZINC000014708529 Inhibitor / Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown
HY-156489 Epigenetic factor-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt7 NCBI NCBI:51547