HLA-DRA - major histocompatibility complex, class II, DR alpha Gene

Also Known as HLA-DRA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3122

About HLA-DRA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,439,887-32,445,046 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 148 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 921.6), lung (RPKM 809.6) and 24 other tissues.

Summary

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

HLA-DRA Products (1)

mRNA Protein Name
NM_019111.5 NP_061984.2 HLA class II histocompatibility antigen, DR alpha chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables T cell receptor binding IDA
IDA: Inferred from direct assay
29884618 GOA
enables peptide antigen binding IDA
IDA: Inferred from direct assay
1448172 GOA
enables polysaccharide binding IDA
IDA: Inferred from direct assay
21502329 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9354468 GOA
Biological Process GO Annotation Evidence References Source
involved in antigen processing and presentation of endogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
15322540 GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
15265931 GOA
involved in antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IDA
IDA: Inferred from direct assay
21502329 GOA
involved in cognition IMP
IMP: Inferred from mutant phenotype
23227193 GOA
involved in myeloid dendritic cell antigen processing and presentation IDA
IDA: Inferred from direct assay
29884618 GOA
involved in peptide antigen assembly with MHC class II protein complex IDA
IDA: Inferred from direct assay
1448172 GOA
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IDA
IDA: Inferred from direct assay
28467828 GOA
involved in positive regulation of CD4-positive, alpha-beta T cell activation IDA
IDA: Inferred from direct assay
15265931 GOA
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
29884618 GOA
involved in positive regulation of memory T cell differentiation IDA
IDA: Inferred from direct assay
27591323 GOA
involved in regulation of T-helper cell differentiation IDA
IDA: Inferred from direct assay
15322540 GOA
Cellular Component GO Annotation Evidence References Source
part of MHC class II protein complex IDA
IDA: Inferred from direct assay
1448172 GOA
part of MHC class II protein complex IMP
IMP: Inferred from mutant phenotype
9354468 GOA
located in cell surface IDA
IDA: Inferred from direct assay
21502329 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
15322540 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
9075930 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
9075930 GOA
located in lysosome IDA
IDA: Inferred from direct assay
8890155 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8890155 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DRA Protein Structure

MHC_II_alpha

MHC_II_alpha: Class II histocompatibility antigen, alpha domain (29 - 109)

C1-set

C1-set: Immunoglobulin C1-set domain (111 - 174)

  • 0
  • 100
  • 200
  • 229 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DR alpha chain

  • MHC class II antigen DRA

HLA-DRA Antibodies

Cat. No. Product Name Application Reactivity
HY-P83339 HLA-DR Antibody (YA3084) WB, IHC-P, ICC/IF, FC Human
HY-P83916 HLA-DR Antibody (YA3613) WB, ICC/IF, FC, ELISA Human
HY-P83916A HLA-DR Antibody (YA3613)(PBS only) WB, ICC/IF, FC, ELISA Human
HY-P85015 HLA-DR Antibody (YA4707) ELISA Human
HY-P86487 HLA-DR Antibody (YA6179) WB, IHC-P, ICC/IF, IP, ELISA Human, Rat

Related Diseases

Diseases Alias
Graham-Little-Piccardi-Lassueur Syndrome

  • Graham Little Syndrome

  • Graham Little-Piccardi-Lassueur Syndrome

  • Piccardi-Lassueur-Little Syndrome

  • Lichen Planus Follicularis
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Gallbladder Melanoma

  • Malignant Melanoma Of Gallbladder
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06210 HLA-DRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HLA-DRA MGD MGI:95900
Rattus norvegicus HLA-DRA RGD RGD:1593283