IFRD1 - interferon related developmental regulator 1 Gene
Also Known as PC4; TIS7
Species: Homo sapiens
About IFRD1
This gene has 22 transcripts (splice variants), 216 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 30.1), pancreas (RPKM 9.7) and 25 other tissues.
Summary
This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
IFRD1 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001007245.3 | NP_001007246.1 | interferon-related developmental regulator 1 isoform 1 |
| NM_001197079.2 | NP_001184008.1 | interferon-related developmental regulator 1 isoform 2 |
| NM_001197080.2 | NP_001184009.1 | interferon-related developmental regulator 1 isoform 2 |
| NM_001550.4 | NP_001541.2 | interferon-related developmental regulator 1 isoform 1 |
IFRD1 Protein Structure
IFRD: Interferon-related developmental regulator (IFRD) (42 - 347)
IFRD_C: Interferon-related protein conserved region (392 - 447)
- 0
- 100
- 200
- 300
- 400
- 451 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interferon-related developmental regulator 1 |
|
IFRD1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82762 | IFRD1 Antibody (YA2507) | WB | Human |
| HY-P82762A | IFRD1 Antibody (YA2507)(PBS only) | WB | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spinocerebellar Ataxia 18 |
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| Lung Disease |
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| Cystic Fibrosis |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | IFRD1 | VGNC | VGNC:81331 |
| Rattus norvegicus | IFRD1 | RGD | RGD:2867 |
| Canis familiaris | IFRD1 | VGNC | VGNC:41882 |
| Felis catus | IFRD1 | VGNC | VGNC:67708 |
| Bos taurus | IFRD1 | VGNC | VGNC:30062 |
| Mus musculus | IFRD1 | MGD | MGI:1316717 |
| Others | IFRD1 | NCBI |