LILRA5 - leukocyte immunoglobulin like receptor A5 Gene

Also Known as CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 353514

About LILRA5

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,307,070-54,313,166 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 295 orthologues and 25 paralogues. Biased expression in appendix (RPKM 29.5), bone marrow (RPKM 22.9) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

LILRA5 Products (4)

mRNA Protein Name
NM_021250.4 NP_067073.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 1 precursor
NM_181879.3 NP_870994.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 3
NM_181985.4 NP_871714.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 2
NM_181986.3 NP_871715.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
19009525 GOA
involved in negative regulation of interleukin-13 production IDA
IDA: Inferred from direct assay
19009525 GOA
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19009525 GOA
involved in positive regulation of calcium ion transport IDA
IDA: Inferred from direct assay
12393390 GOA
involved in positive regulation of cell activation IDA
IDA: Inferred from direct assay
12393390 GOA
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
12393390 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
12393390 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
19009525 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
12393390 GOA
involved in positive regulation of protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
19009525 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
12393390 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19009525 GOA
located in extracellular space IMP
IMP: Inferred from mutant phenotype
12393390 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRA5 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (48 - 135)

Ig_3

Ig_3: Immunoglobulin domain (141 - 217)

  • 0
  • 100
  • 200
  • 265 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily A member 5

  • CD85 antigen-like family member F

Recombinant LILRA5 Proteins

Cat. No. Product Name Accession Purity
HY-P72394 LILRA5/CD85f Protein, Human (Biotinylated, HEK293, His-Avi) A6NI73-1 (G42-R268) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72521 LILRA5/CD85f Protein, Human (HEK293, His) A6NI73-1 (G42-R268) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75909 LILRA5/CD85f Protein, Human (Biotinylated, HEK293, His) A6NI73-1 (G42-R268) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75910 LILRA5/CD85f Protein, Human (HEK293, Fc) A6NI73-1 (G42-R268) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78481 LILRA5/CD85f Protein, Human (HEK293, His-Avi) A6NI73-1 (G42-R268) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07649 LILRA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19514 Lilra5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26008 Lilra5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LILRA5 RGD RGD:1582781
Mus musculus LILRA5 MGD MGI:3647196
Macaca mulatta LILRA5 VGNC VGNC:82174
Others LILRA5 NCBI