INPP1 - inositol polyphosphate-1-phosphatase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3628

About INPP1

Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:190,343,589-190,371,665 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 21.9), esophagus (RPKM 18.0) and 24 other tissues.

Summary

This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the Enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

INPP1 Products (2)

mRNA Protein Name
NM_001128928.2 NP_001122400.1 inositol polyphosphate 1-phosphatase
NM_002194.4 NP_002185.1 inositol polyphosphate 1-phosphatase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26871637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP1 Protein Structure

Inositol_P

Inositol_P: Inositol monophosphatase family (57 - 378)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

inositol polyphosphate 1-phosphatase

  • IPP

INPP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INPP1 P49441 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
26871637
Intra
INPP1 P49441 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
26871637
Intra
INPP1 P49441 MEOX2 Homo sapiens Q6FHY5
Y2H Array
26871637
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INPP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70361 INPP1 Protein, Human (HEK293, His) P49441 (M1-T399) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Ring Dermoid Of Cornea

  • RDC

  • Ring Dermoid Syndrome

  • Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension

  • Dermoid Of Cornea, Ring
Cone-Rod Dystrophy 5

  • CORD5

  • Dystrophy, Cone-Rod, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151374 3-IN-PP1 Inhibitor 99.37% Unkown
HY-RS06824 INPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20041 Inpp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26544 Inpp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris INPP1 VGNC VGNC:42027
Rattus norvegicus INPP1 RGD RGD:1306071
Bos taurus INPP1 VGNC VGNC:30208
Macaca mulatta INPP1 VGNC VGNC:73746
Felis catus INPP1 VGNC VGNC:107567
Mus musculus INPP1 MGD MGI:104848
Others INPP1 NCBI