Itk - IL2-inducible T-cell kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363577

About Itk

Primary_assembly 10: 30,753,344-30,814,685 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 208 orthologues, 32 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 583.1) and Spleen (RPKM 71.5).

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including T cell activation; activation of Phospholipase C activity; and antigen receptor-mediated signaling pathway. Predicted to be located in several cellular components, including cell-cell junction; cytosol; and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human Itk (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Apr 2022]

Itk Products (1)

mRNA Protein Name
NM_001108825.2 NP_001102295.2 tyrosine-protein kinase ITK/TSK

Itk Protein Structure

PH_Btk

PH_Btk: cd01238 (6 - 147)

SH3_ITK

SH3_ITK: cd11908 (173 - 228)

SH2_Tec_Itk

SH2_Tec_Itk: cd10396 (231 - 339)

PTKc_Itk

PTKc_Itk: cd05112 (357 - 612)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 620 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase ITK/TSK

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-150298 Soquelitinib Inhibitor 99.98% Phase 3
HY-109078 Vecabrutinib Inhibitor 99.76% Phase 2

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-11092 BMS-509744 Inhibitor 98.05% Unkown
HY-12680 PRN694 Inhibitor ≥99.0% Unkown
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-101321A Immepip dihydrobromide Degrader 99.98% Unkown
HY-128726 ITK inhibitor 2 Inhibitor 99.50% Unkown
HY-12410 GNE-9822 Inhibitor 98.47% Unkown
HY-169396 TAE648 Ligand 99.50% Unkown
HY-120559 GSK-2250665A Inhibitor 96.35% Unkown
HY-185206 BSJ-05-037 Degrader 99.83% Unkown
HY-174280 Modzatinib Inhibitor / Unkown
HY-150023 BI-1622 Inhibitor 98.02% Unkown
HY-146672 ITK inhibitor 6 Inhibitor / Unkown
HY-13232 ITK antagonist Inhibitor / Unkown
HY-174903 ITK-IN-6 Inhibitor 99.02% Unkown
HY-149917 PROTAC ITK degrader 1 Degrader / Unkown
HY-N6857C (±)-Armepavine hydrochloride / Unkown
HY-184275 ITK-IN-7 Inhibitor / Unkown
HY-16984 GNE-4997 Inhibitor / Unkown
HY-182335 PF-07245303 Inhibitor / Unkown
HY-143901 EGFR-IN-40 Inhibitor / Unkown
HY-153322 ITK degrader 2 Degrader / Unkown
HY-168963 PROTAC BTK Degrader-13 Inhibitor / Unkown
HY-141864 ITK/TRKA-IN-1 Inhibitor / Unkown
HY-146671 ITK inhibitor 5 Inhibitor / Unkown
HY-E70833 ITK Recombinant Human Active Protein Kinase / Unkown
HY-168387 ITK ligand 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itk NCBI NCBI:3702