TAFA1 - TAFA chemokine like family member 1 Gene

Homo sapiens

Also known as TAFA-1; FAM19A1

Gene ID: 407738 | Gene type: protein coding

About TAFA1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:67,991,544-68,545,621 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 3 paralogues. Biased expression in brain (RPKM 6.6) and prostate (RPKM 0.3).

Summary

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

TAFA1 Products(2)

mRNA	Protein	Name
NM_001252216.2	NP_001239145.1	chemokine-like protein TAFA-1 precursor
NM_213609.4	NP_998774.2	chemokine-like protein TAFA-1 precursor

TAFA1 Protein Structure

TAFA

0
100
133 a.a.

Protein Preferred Names

Protein Names

chemokine-like protein TAFA-1

family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

Recombinant TAFA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79169	TAFA1/FAM19A1 Protein, Human	NP_998774 (S26-T133)	≥95%

Related Diseases

Diseases

Alias

Lissencephaly 9 With Complex Brainstem Malformation

LIS9	Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14179	TAFA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TAFA1	VGNC	VGNC:78188
Rattus norvegicus	TAFA1	RGD	RGD:1563030
Bos taurus	TAFA1	VGNC	VGNC:28777
Mus musculus	TAFA1	MGD	MGI:2443695
Canis familiaris	TAFA1	VGNC	VGNC:82300
Felis catus	TAFA1	VGNC	VGNC:102710
Others	TAFA1	NCBI

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