TAFA1 - TAFA chemokine like family member 1 Gene

Also Known as TAFA-1; FAM19A1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 407738

About TAFA1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:67,991,544-68,545,621 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 3 paralogues. Biased expression in brain (RPKM 6.6) and prostate (RPKM 0.3).

Summary

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

TAFA1 Products (2)

mRNA Protein Name
NM_001252216.2 NP_001239145.1 chemokine-like protein TAFA-1 precursor
NM_213609.4 NP_998774.2 chemokine-like protein TAFA-1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in extracellular space IDA
IDA: Inferred from direct assay
29453251 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAFA1 Protein Structure

TAFA

TAFA: TAFA family (41 - 129)

  • 0
  • 100
  • 133 a.a.
Protein Preferred Names Protein Names

chemokine-like protein TAFA-1

  • family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

TAFA1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TAFA1 Q7Z5A9 RABGGTB Homo sapiens P53611
Y2H Array
25416956
Intra
TAFA1 Q7Z5A9 RABGGTB Homo sapiens P53611
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TAFA1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P79169 TAFA1/FAM19A1 Protein, Human Q7Z5A9/NP_998774 (S26-T133) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Lissencephaly 9 With Complex Brainstem Malformation

  • LIS9

  • Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome
Williams-Beuren Syndrome

  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14179 TAFA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21779 Tafa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28296 Tafa1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta TAFA1 VGNC VGNC:78188
Rattus norvegicus TAFA1 RGD RGD:1563030
Bos taurus TAFA1 VGNC VGNC:28777
Mus musculus TAFA1 MGD MGI:2443695
Canis familiaris TAFA1 VGNC VGNC:82300
Felis catus TAFA1 VGNC VGNC:102710
Others TAFA1 NCBI