MFGE8 - milk fat globule EGF and factor V/VIII domain containing Gene

Also Known as BA46; HMFG; MFGM; SED1; hP47; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4240

About MFGE8

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,898,683-88,913,379 (from NCBI)

This gene has 23 transcripts (splice variants), 278 orthologues and 35 paralogues. Broad expression in heart (RPKM 68.1), endometrium (RPKM 47.7) and 22 other tissues.

Summary

This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and Cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

MFGE8 Products (5)

mRNA Protein Name
NM_001114614.3 NP_001108086.1 lactadherin isoform b precursor
NM_001310319.2 NP_001297248.1 lactadherin isoform d precursor
NM_001310320.2 NP_001297249.1 lactadherin isoform c
NM_001310321.2 NP_001297250.1 lactadherin isoform e
NM_005928.4 NP_005919.2 lactadherin isoform a preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables phosphatidylserine binding IPI
IPI: Inferred from physical interaction
21196491 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MFGE8 Protein Structure

EGF

EGF: EGF-like domain (27 - 64)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (86 - 222)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (245 - 384)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

lactadherin

  • O-acetyl disialoganglioside synthase

Recombinant MFGE8 Proteins

Cat. No. Product Name Accession Purity
HY-P73815 MFG-E8 Protein, Human (sf9, His) Q08431-1 (L24-C387) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P73816 MFG-E8 Protein, Human (Biotinylated, sf9, His-Avi) Q08431-1 (L24-C387) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Topographical Agnosia
Opisthorchiasis

  • Infection By Opisthorchis

  • Infection Due To Opisthorchis

  • Infection Due To Cat Liver Fluke

  • Infection By Cat Liver Fluke

  • Opisthorchiosis

  • Cat Liver Fluke Fever

  • Cat Liver Fluke Disease

  • Opisthorchis Infestation

  • Cat Liver Fluke Infestation
Anal Paget'S Disease

  • Anal Paget Disease

  • Paget'S Disease Of Anus

  • Paget'S Disease Of The Anus

  • Paget Disease Of The Anus
Diamond-Blackfan Anemia 9

  • DBA9

  • Rps10-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 9
Hidrocystoma

  • Apocrine Cystadenoma

  • Eccrine Hidrocystoma

  • Eccrine Cystadenoma

  • Eccrine Hidrocystoma Of Skin

  • Apocrine Adenoma
Sexual Sadism

  • Sadism
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Aortic Aneurysm, Familial Thoracic 1

  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Familial Thoracic Aortic Aneurysm

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08381 MFGE8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19023 Mfge8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25512 Mfge8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MFGE8 VGNC VGNC:68242
Mus musculus MFGE8 MGD MGI:102768
Bos taurus MFGE8 VGNC VGNC:31426
Canis familiaris MFGE8 VGNC VGNC:53186
Rattus norvegicus MFGE8 RGD RGD:3083
Others MFGE8 NCBI