MYO1F - myosin IF Gene

Homo sapiens

Gene ID: 4542 | Gene type: protein coding

About MYO1F

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,520,778-8,577,442 (from NCBI)

This gene has 22 transcripts (splice variants), 206 orthologues and 43 paralogues. Biased expression in bone marrow (RPKM 41.2), spleen (RPKM 33.9) and 13 other tissues.

Summary

Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional Myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]

MYO1F Products(2)

mRNA	Protein	Name
NM_001348355.2	NP_001335284.1	unconventional myosin-If isoform 2
NM_012335.4	NP_036467.2	unconventional myosin-If isoform 1

MYO1F Protein Structure

Myosin_head

Myosin_TH1

SH3_9

0
200
400
600
800
1000
1098 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-If

myosin-ID

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 12

Epileptic Encephalopathy, Early Infantile, 12	DEE12
Eiee12	Early Infantile Epileptic Encephalopathy 12
Developmental And Epileptic Encephalopathy, 12	Encephalopathy, Epileptic, Early Infantile, Type 12

Floating-Harbor Syndrome

FLHS	Fhs
Pelletier-Leisti Syndrome	Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes
Leisti-Hollander-Rimoin Syndrome

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08942	MYO1F Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYO1F	MGD	MGI:107711
Felis catus	MYO1F	VGNC	VGNC:68394
Bos taurus	MYO1F	VGNC	VGNC:31821
Rattus norvegicus	MYO1F	RGD	RGD:1309750
Canis familiaris	MYO1F	VGNC	VGNC:43565

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