MYO1F - myosin IF Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4542

About MYO1F

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,520,778-8,577,442 (from NCBI)

This gene has 22 transcripts (splice variants), 206 orthologues and 43 paralogues. Biased expression in bone marrow (RPKM 41.2), spleen (RPKM 33.9) and 13 other tissues.

Summary

Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional Myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]

MYO1F Products (2)

mRNA	Protein	Name
NM_001348355.2	NP_001335284.1	unconventional myosin-If isoform 2
NM_012335.4	NP_036467.2	unconventional myosin-If isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO1F Protein Structure

Myosin_head

Myosin_TH1

SH3_9

0
200
400
600
800
1000
1098 a.a.

Protein Preferred Names	Protein Names
unconventional myosin-If	myosin-ID

MYO1F Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MYO1F	O00160	OSTF1	Homo sapiens	Q92882	Anti Tag CoIP	33961781
Intra	MYO1F	O00160	OSTF1	Homo sapiens	Q92882	Anti Tag CoIP	28514442
Intra	MYO1F	O00160	SH3BP2	Homo sapiens	P78314-3	Validated Y2H	32296183
Intra	MYO1F	O00160	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	MYO1F	O00160	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 12	Epileptic Encephalopathy, Early Infantile, 12 DEE12 Eiee12 Early Infantile Epileptic Encephalopathy 12 Developmental And Epileptic Encephalopathy, 12 Encephalopathy, Epileptic, Early Infantile, Type 12
Floating-Harbor Syndrome	FLHS Fhs Pelletier-Leisti Syndrome Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes Leisti-Hollander-Rimoin Syndrome
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08942	MYO1F Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYO1F	MGD	MGI:107711
Felis catus	MYO1F	VGNC	VGNC:68394
Bos taurus	MYO1F	VGNC	VGNC:31821
Rattus norvegicus	MYO1F	RGD	RGD:1309750
Canis familiaris	MYO1F	VGNC	VGNC:43565
Others	MYO1F	NCBI