OGN - osteoglycin Gene

Also Known as OG; OIF; SLRR3A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4969

About OGN

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,383,268-92,404,699 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues.

Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

OGN Products (3)

mRNA Protein Name
NM_014057.5 NP_054776.1 mimecan isoform 2 precursor
NM_024416.4 NP_077727.3 mimecan isoform 1
NM_033014.4 NP_148935.1 mimecan isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OGN Protein Structure

LRR_8

LRR_8: Leucine rich repeat (123 - 179)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

mimecan

  • corneal keratan sulfate proteoglycan

OGN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OGN P20774 CRK Homo sapiens P46108
Peptide Array
17474147
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OGN Proteins

Cat. No. Product Name Accession Purity
HY-P74664 OGN/Osteoglycin Protein, Human (HEK293, His) P20774 (P21-F298) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Diseases

Diseases Alias
Inhibited Male Orgasm

  • Male Orgasmic Disorder

  • Psychosexual Dysfunction With Male Orgasmic Disorder
Adjustment Disorder

  • Adjustment Reaction

  • Adjustment Disorders

  • Adjustment Disease

  • Brief Situational Non-Psychotic Disorder

  • Adaptation Reaction Nos

  • Emotional Crisis

  • Situational Disorder

  • Situational Disturbance

  • Situational Maladjustment

  • Situational Reaction

  • Situational Reaction With Maladjustment

  • Transient Situational Disturbance
Combat Disorder

  • Combat Disorders

  • Combat Neurosis
Plantar Fascial Fibromatosis

  • Dupuytren'S Contracture Of Foot

  • Ledderhose'S Disease

  • Fibromatosis, Plantar

  • Ledderhose Disease
Post-Traumatic Stress Disorder

  • PTSD

  • Traumatic Neurosis

  • Post Traumatic Stress Disorder

  • Stress Disorders, Post-Traumatic

  • Posttraumatic Stress Disorder

  • Ptsd - [Post Traumatic Stress Disorder]

  • Trauma-Related Disorders
Dissociative Amnesia

  • Psychogenic Amnesia

  • Amnesia, Dissociative

  • Amnesia, Psychogenic

  • Amnesia Neurosis

  • Hysterical Fugue

  • Dissociative Fugue
Dissociative Disorder

  • Dissociative Disorders

  • Dissociative Disease

  • Dissociative Reaction
Psammomatous Meningioma
Acute Stress Disorder

  • Traumatic Stress Disorder

  • Stress Disorders, Traumatic, Acute

  • Stress Disorders, Traumatic
Macular Dystrophy, Corneal

  • Macular Corneal Dystrophy

  • MCD

  • Corneal Dystrophy, Macular Type

  • Groenouw Type Ii Corneal Dystrophy

  • Fehr Corneal Dystrophy

  • Macular Dystrophy, Corneal Type 1

  • Mcdc1

  • Macular Corneal Dystrophy Type Ii

  • Macular Corneal Dystrophy, Type Ii

  • Macular Corneal Dystrophy, Type I

  • Mcdc1, Formerly

  • Macular Dystrophy, Corneal, 1

  • Macular Corneal Dystrophy Type 1

  • Corneal Dystrophy Groenouw Type Ii

  • Corneal Dystrophy Macular Type

  • Macular Corneal Dystrophy Type I

  • Dystrophy, Macular, Corneal
Vaginal Cancer

  • Malignant Neoplasm Of Vagina

  • Vaginal Neoplasms

  • Malignant Tumor Of Vagina

  • Malignant Vaginal Tumor

  • Neoplasm Of Vagina

  • Vagina Neoplasm

  • Vaginal Tumor

  • Vaginal Carcinoma

  • Vaginal Malignant Epithelial Tumor

  • Vaginal Neoplasm

  • Malignant Vaginal Neoplasm

  • Vagina Carcinoma

  • Vaginal Neoplasia

  • Cancer Of Vagina

  • Malignant Tumour Of Vagina

  • Carcinoma Of Vagina

  • Primary Malignant Neoplasm Of Vagina

  • Vagina Wall Cancer

  • Vaginal Wall Cancer
Multiple Personality Disorder

  • Dissociative Identity Disorder

  • Multiple Personality
Cornea Plana

  • Flat Cornea
Amnestic Disorder

  • Amnesia

  • Amnestic Syndrome

  • Korsakoff'S Psychosis Or Syndrome

  • Amnesic Syndrome

  • Amnestic Disorder In Conditions Classified Elsewhere

  • Korsakoff Psychosis Or Syndrome, Nonalcoholic

  • Nonalcoholic Organic Amnesic Syndrome

  • Organic Amnesic Syndrome
Substance Abuse

  • Substance-Related Disorders

  • Substance Abuse Problem
Alcohol Use Disorder

  • Alcohol Abuse

  • Alcoholism

  • Ethanol Abuse

  • Alcohol Addiction

  • Alcohol Dependence

  • Alcoholic Intoxication, Chronic

  • Alcohol-Related Disorders
Stromal Dystrophy
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09764 OGN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18219 Ogn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24696 Ogn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris OGN VGNC VGNC:44110
Rattus norvegicus OGN RGD RGD:1308171
Felis catus OGN VGNC VGNC:68622
Mus musculus OGN MGD MGI:109278
Macaca mulatta OGN VGNC VGNC:75582
Bos taurus OGN VGNC VGNC:32414
Others OGN NCBI