CLDN11 - claudin 11 Gene

Also Known as OSP; OTM; HLD22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5010

About CLDN11

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,418,868-170,434,691 (from NCBI)

This gene has 7 transcripts (splice variants), 265 orthologues, 22 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 84.9), brain (RPKM 41.6) and 2 other tissues.

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

CLDN11 Products (2)

mRNA	Protein	Name
NM_001185056.2	NP_001171985.1	claudin-11 isoform 2 precursor
NM_005602.6	NP_005593.2	claudin-11 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	30734065	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20375010	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in tight junction assembly	IDA IDA: Inferred from direct assay	30734065	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	30734065	GOA
located in neurofilament	IDA IDA: Inferred from direct assay	30734065	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20375010	GOA
located in tight junction	IDA IDA: Inferred from direct assay	30734065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN11 Protein Structure

PMP22_Claudin

0
100
207 a.a.

Protein Preferred Names	Protein Names
claudin-11	oligodendrocyte transmembrane protein

CLDN11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLDN11	O75508	SHISA3	Homo sapiens	A0PJX4	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	SHISA3	Homo sapiens	A0PJX4	Y2H Array	32296183
Intra	CLDN11	O75508	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	CLDN11	O75508	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	CLDN11	O75508	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	CLDN11	O75508	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	CLDN11	O75508	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	CLDN11	O75508	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	CLDN11	O75508	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	CLDN11	O75508	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	CLDN11	O75508	ZP3	Homo sapiens	P21754-3	Validated Y2H	32296183
Intra	CLDN11	O75508	ZP3	Homo sapiens	P21754-3	Y2H Array	32296183
Intra	CLDN11	O75508	ZP3	Homo sapiens	P21754-3	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	C16orf54	Homo sapiens	Q6UWD8	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	C16orf54	Homo sapiens	Q6UWD8	Y2H Array	32296183
Intra	CLDN11	O75508	C16orf54	Homo sapiens	Q6UWD8	Validated Y2H	32296183
Intra	CLDN11	O75508	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	CLDN11	O75508	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	CLDN11	O75508	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	CLDN11	O75508	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	CLDN11	O75508	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	CLDN11	O75508	TNFSF14	Homo sapiens	O43557	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	TNFSF14	Homo sapiens	O43557	Y2H Array	32296183
Intra	CLDN11	O75508	SMIM3	Homo sapiens	Q9BZL3	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	CLDN11	O75508	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	32296183
Intra	CLDN11	O75508	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	CLDN11	O75508	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	CLDN11	O75508	KLRC1	Homo sapiens	P26715	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74250	Claudin-11/CLDN11 Protein, Human (HEK293, Fc)	O75508 (V23-R82)	≥ 90%, as determined by reducing SDS-PAGE.

CLDN11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810905	Claudin 11 Antibody	WB, ICC/IF	Human, Mouse, Rat
HY-P82589	Claudin 11 Antibody (YA2334)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Leukodystrophy, Hypomyelinating, 22	HLD22
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Hypomyelinating Leukodystrophy	Hld Leukodystrophy, Hypomyelinating
Leukodystrophy	Leukodystrophies
Deafness, Autosomal Recessive 29	DFNB29 Autosomal Recessive Nonsyndromic Deafness 29 Autosomal Recessive Deafness 29 Deafness, Autosomal Recessive, 29 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29 Deafness, Autosomal Recessive, Type 29
Amyotrophic Lateral Sclerosis 3	ALS3 Amyotrophic Lateral Sclerosis Type 3
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Pyriform Sinus Cancer	Malignant Neoplasm Of Pyriform Fossa Malignant Neoplasm Of The Pyriform Fossa Malignant Tumor Of Pyriform Fossa
Acrodermatitis Chronica Atrophicans	Acrodermatitis Atrophicans Chronica Herxheimer Disease Primary Diffuse Atrophy
Orchitis	Inflammation Of Testis Orchititis Mumps Orchitis
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Leukoencephalopathy With Vanishing White Matter	Cree Leukoencephalopathy Vanishing White Matter Disease Ovarioleukodystrophy Vanishing White Matter Leukodystrophy Childhood Ataxia With Central Nervous System Hypomyelinization Cach Cach Syndrome Myelinosis Centralis Diffusa VWM Cle Childhood Ataxia With Central Nervous System Hypomyelination Childhood Ataxia With Diffuse Central Nervous System Hypomyelination Cach/Vwm Cach/Vwm Syndrome Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter Cree Leukoencehalopathy Late Infantile Cach Syndrome Juvenile Or Adult Cach Syndrome Congenital Or Early Infantile Cach Syndrome Leukodystrophy With Vanishing White Matter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02764	CLDN11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20144	Cldn11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26648	Cldn11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLDN11	RGD	RGD:71081
Canis familiaris	CLDN11	VGNC	VGNC:49935
Macaca mulatta	CLDN11	VGNC	VGNC:81181
Bos taurus	CLDN11	VGNC	VGNC:53517
Felis catus	CLDN11	VGNC	VGNC:102671
Mus musculus	CLDN11	MGD	MGI:106925
Others	CLDN11	NCBI