2. Gene
  3. Huwe1 - HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Gene

Huwe1 - HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as URE-B1

Gene ID: 501546 | Gene type: protein coding

About Huwe1

Summary

Enables DNA binding activity. Predicted to be involved in several processes, including circadian regulation of gene expression; positive regulation of protein metabolic process; and protein ubiquitination. Located in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Huwe1 Products(1)

mRNA Protein Name
NM_001408927.1 NP_001395856.1 E3 ubiquitin-protein ligase HUWE1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
7968380 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
27191843 RGD
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
7968380 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HUWE1

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase

HECT, UBA and WWE domain-containing protein 1

HECT-type E3 ubiquitin transferase HUWE1

URE-binding protein 1

upstream regulatory element-binding protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120929 BI8622 Inhibitor 98.28% Unkown
HY-120204 BI8626 Inhibitor 99.20% Unkown
HY-RS06493 HUWE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Huwe1 NCBI NCBI:10075