PALM - paralemmin Gene

Also Known as PALM1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5064

About PALM

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:708,935-748,329 (from NCBI)

This gene has 11 transcripts (splice variants), 235 orthologues and 3 paralogues. Broad expression in fat (RPKM 28.7), brain (RPKM 22.8) and 18 other tissues.

Summary

This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and Other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

PALM Products (2)

mRNA Protein Name
NM_001040134.2 NP_001035224.1 paralemmin-1 isoform 2
NM_002579.3 NP_002570.2 paralemmin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16386234 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
16386234 GOA
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
14978216 GOA
Cellular Component GO Annotation Evidence References Source
located in filopodium membrane IDA
IDA: Inferred from direct assay
14978216 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16386234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALM Protein Structure

Paralemmin

Paralemmin: Paralemmin (71 - 387)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

paralemmin-1

PALM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PALM O75781 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
PALM O75781 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
PALM O75781 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Osteopetrosis, Autosomal Dominant 2

  • OPTA2

  • Autosomal Dominant Osteopetrosis 2

  • Osteopetrosis Autosomal Dominant Type 2

  • Osteopetrosis, Autosomal Dominant, Type Ii

  • Albers-Schonberg Osteopetrosis

  • Autosomal Dominant Albers-Schonberg Disease

  • Osteopetrosis

  • Marble Bones, Autosomal Dominant

  • Osteosclerosis Fragilis Generalisata

  • Albers-Schonberg Disease, Autosomal Dominant

  • Autosomal Dominant Osteopetrosis Type Ii

  • Albers-Schönberg Osteopetrosis

  • Autosomal Dominant Osteopetrosis Type 2

  • Marble Disease Autosomal Dominant

  • Osteopetrosis, Autosomal Dominant, Type 2
Pettigrew Syndrome

  • PGS

  • Mrxs5

  • Mrx59

  • Mrxs21

  • X-Linked Intellectual Disability-Dandy-Walker Malformation-Basal Ganglia Disease-Seizures Syndrome

  • Mental Retardation, X-Linked, Syndromic 5

  • Mrxsf

  • Syndromic X-Linked Intellectual Disability 5

  • Fried Syndrome

  • Mental Retardation, X-Linked Syndromic 5

  • Mental Retardation, X-Linked, With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures

  • Mental Retardation, X-Linked, Syndromic, Fried Type

  • Mental Retardation, X-Linked, Syndromic 21

  • Syndromic X-Linked Mental Retardation 21

  • Syndromic X-Linked Mental Retardation Fried Type

  • X-Linked Metal Retardation With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures

  • Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease An

  • Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease And Seizures

  • X-Linked Syndromic Intellectual Disability 5

  • X-Linked Intellectual Disability With Dandy-Walker Malformation Basal Ganglia Disease And Seizures

  • X-Linked Intellectual Disability - Dandy-Walker Malformation - Basal Ganglia Disease - Seizures

  • X-Linked Intellectual Disability-Hypotonia-Facial Dysmorphism-Aggressive Behavior Syndrome

  • Mental Retardation, X-Linked Syndromic, Fried Type

  • Dandy-Walker Malformation With Mental Retardation, Basal Ganglia Disease, And Seizures

  • Mental Retardation, X-Linked 59
Differentiating Neuroblastoma
Isolated Growth Hormone Deficiency, Type Ii

  • Ighd Ii

  • Isolated Growth Hormone Deficiency Type Ii

  • IGHD2

  • Growth Hormone Deficiency, Isolated, Type Ii

  • Congenital Ighd Type Ii

  • Congenital Isolated Gh Deficiency Type Ii

  • Congenital Isolated Growth Hormone Deficiency Type Ii

  • Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant

  • Growth Hormone Deficiency, Isolated, Autosomal Dominant

  • Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant

  • Autosomal Dominant Isolated Growth Hormone Deficiency

  • Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency

  • Isolated Growth Hormone Deficiency Type 2

  • Growth Hormone Deficiency, Isolated Autosomal Dominant

  • Growth Hormone Deficiency, Isolated, 2

  • Growth Hormone Deficiency Isolated Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-170223 Palm oil / Phase 4
HY-P10031 SAR441255 Agonist 99.84% Phase 1
HY-120634 BMS-929075 Inhibitor / Phase 1
HY-N2041S8 Myristic acid-13C2 / Phase 1

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2041 Myristic acid 99.88% Unkown
HY-N0773 Isovitexin Inhibitor 99.90% Unkown
HY-N2041S Myristic acid-d27 98.83% Unkown
HY-P10932A pGk13a TFA 96.92% Unkown
HY-108693 β-Tocotrienol Inducer 99.14% Unkown
HY-145519 Mu-6S-Palm-β-Glc 99.9% Unkown
HY-P0064 Palmitoyl Tetrapeptide-3 Inhibitor 99.18% Unkown
HY-W100026 Galaxolide 76.44% Unkown
HY-N2041S3 Myristic acid-d3 98.62% Unkown
HY-148702 di-Pal-MTO 98.37% Unkown
HY-D1196 Direct Blue 71 / Unkown
HY-P10031A SAR441255 TFA Agonist 99.93% Unkown
HY-N2041S6 Myristic acid-d5 98.0% Unkown
HY-W250170 Decyl glucoside (60% in water) / Unkown
HY-W013788 2-Palmitoylglycerol Agonist 99.0% Unkown
HY-N2041S2 Myristic acid-13C 99.39% Unkown
HY-N2041S7 Myristic acid-d7 99.80% Unkown
HY-P10380A palm11-PrRP31 TFA Agonist 99.44% Unkown
HY-W038795 (S)-Ethyl lactate 99.83% Unkown
HY-N2041S1 Myristic acid-d2 98.0% Unkown
HY-N2041S4 Myristic acid-13C3 99.9% Unkown
HY-W099600 Lauric anhydride 97.0% Unkown
HY-B0828 Triazophos Inhibitor 99.25% Unkown
HY-W010667 (Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate 98.01% Unkown
HY-W111403 Calcium oxide 99.9% Unkown
HY-128430 Farnesyl acetate Inhibitor 90% Unkown
HY-148701 mono-Pal-MTO / Unkown
HY-157172 MorHap Inhibitor / Unkown
HY-D3157 Photoactive esterase probe / Unkown
HY-N19229 Dihydrocitrinone / Unkown
HY-N2041S5 Myristic acid-d1 / Unkown
HY-N20847 Windmill palm leaves polysaccharides / Unkown
HY-P10379 palm-PrRP31 Agonist / Unkown
HY-P10380 palm11-PrRP31 Agonist / Unkown
HY-P10932 pGk13a / Unkown
HY-RS10005 PALM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10006 PALM2AKAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10007 PALM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W010736A 1,2-Dipalmitoyl-rac-glycerol / Unkown
HY-W750719 Neurosporene / Unkown
HY-10467 HCV-796 analog Inhibitor / Unkown
HY-179357 Hydrogenated palm oil / Unkown
HY-179358 Hydrogenated palm oil glycerides / Unkown
HY-B0828S Triazophos-d5 Inhibitor / Unkown
HY-N7813 1,2-Dipalmitoyl-3-oleoylglycerol / Unkown
HY-RS18489 Palm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24971 Palm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W710399 2-Hydroxy-3-(palmitoyloxy)propyl stearate / Unkown
HY-W710976 4-Methyl-5-nonanone 98.47% Unkown
HY-W714197 Methfuroxam Inhibitor / Unkown
HY-W719989 γ-Carotene / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PALM VGNC VGNC:32558
Macaca mulatta PALM VGNC VGNC:75751
Felis catus PALM VGNC VGNC:102653
Canis familiaris PALM VGNC VGNC:54980
Rattus norvegicus PALM RGD RGD:620341
Mus musculus PALM MGD MGI:1261814
Others PALM NCBI