Gsk3a - glycogen synthase kinase 3 alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50686

About Gsk3a

Primary_assembly 1: 80,815,850-80,825,802 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 260 orthologues, 1 paralogue and is associated with 12 phenotypes. Biased expression in Brain (RPKM 162.2), Adrenal (RPKM 117.9) and 9 other tissues.

Summary

Enables protein kinase A catalytic subunit binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of dendrite development; positive regulation of neuron apoptotic process; and protein phosphorylation. Located in cytoplasm and microtubule. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3a Products (1)

mRNA Protein Name
NM_017344.2 NP_059040.1 glycogen synthase kinase-3 alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase A catalytic subunit binding IPI
IPI: Inferred from physical interaction
11035810 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20841359 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
2164470 RGD
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
8524413 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
23470087 RGD
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
8524413 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20841359 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11035810 RGD
Cellular Component GO Annotation Evidence References Source
located in microtubule IDA
IDA: Inferred from direct assay
8576078 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gsk3a Protein Structure

STKc_GSK3

STKc_GSK3: cd14137 (113 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

glycogen synthase kinase-3 alpha

  • FA

  • GSK-3 alpha

  • factor A

  • serine/threonine-protein kinase GSK3A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-W969907 GSK3-IN-7 99.35% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-RS05862 GSK3A Human Pre-designed siRNA Set A / Unkown
HY-RS05863 Gsk3a Mouse Pre-designed siRNA Set A / Unkown
HY-RS05864 Gsk3a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsk3a NCBI NCBI:2931