2. Gene
  3. Gsk3a - glycogen synthase kinase 3 alpha Gene

Gsk3a - glycogen synthase kinase 3 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 50686 | Gene type: protein coding

About Gsk3a

Primary_assembly 1: 80,815,850-80,825,802 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 260 orthologues, 1 paralogue and is associated with 12 phenotypes. Biased expression in Brain (RPKM 162.2), Adrenal (RPKM 117.9) and 9 other tissues.

Summary

Enables protein kinase A catalytic subunit binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of dendrite development; positive regulation of neuron apoptotic process; and protein phosphorylation. Located in cytoplasm and microtubule. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3a Products(1)

mRNA Protein Name
NM_017344.2 NP_059040.1 glycogen synthase kinase-3 alpha

Gsk3a Protein Structure

STKc_GSK3

STKc_GSK3: cd14137 (113 - 412)

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  • 490 a.a.
Protein Preferred Names Protein Names

glycogen synthase kinase-3 alpha

FA

GSK-3 alpha

factor A

serine/threonine-protein kinase GSK3A

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-RS05862 GSK3A Human Pre-designed siRNA Set A / Unkown
HY-RS05863 Gsk3a Mouse Pre-designed siRNA Set A / Unkown
HY-RS05864 Gsk3a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsk3a NCBI NCBI:2931