PDZD11 - PDZ domain containing 11 Gene

Also Known as PISP; AIPP1; PDZK11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51248

About PDZD11

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,286,595-70,289,927 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 12.6), thyroid (RPKM 10.9) and 25 other tissues.

Summary

Enables protein C-terminus binding activity. Involved in pore complex assembly. Located in basolateral plasma membrane and cytosol. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]

PDZD11 Products (6)

mRNA Protein Name
NM_001370174.1 NP_001357103.1 PDZ domain-containing protein 11 isoform 1
NM_001370175.1 NP_001357104.1 PDZ domain-containing protein 11 isoform 1
NM_001370176.1 NP_001357105.1 PDZ domain-containing protein 11 isoform 1
NM_001370177.1 NP_001357106.1 PDZ domain-containing protein 11 isoform 1
NM_001370178.1 NP_001357107.1 PDZ domain-containing protein 11 isoform 2
NM_016484.5 NP_057568.1 PDZ domain-containing protein 11 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12763866 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in pore complex assembly IMP
IMP: Inferred from mutant phenotype
30463011 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12763866 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12763866 GOA
part of pore complex IMP
IMP: Inferred from mutant phenotype
30463011 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDZD11 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (48 - 124)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

PDZ domain-containing protein 11

  • ATPase-interacting PDZ protein

PDZD11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PDZD11 Q5EBL8 MAGI2 Homo sapiens Q86UL8-2
Y2H Prey Pooling
32296183
Intra
PDZD11 Q5EBL8 MAGI2 Homo sapiens Q86UL8-2
Validated Y2H
32296183
Intra
PDZD11 Q5EBL8 MAGI2 Homo sapiens Q86UL8-2
Y2H Array
32296183
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Pull Down
21183659
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Y2H
21183659
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Confocal
21183659
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Anti Tag CoIP
21183659
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Anti Tag CoIP
16051599
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Y2H Pooling
16051599
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Y2H Array
16051599
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Y2H
16051599
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Y2H Array
32296183
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Validated Y2H
32296183
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Y2H Prey Pooling
32296183
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDZD11 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P77130 PDZD11 Protein, Human (His) Q5EBL8-1 (D2-H140) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Purulent Acute Otitis Media

  • Acute Suppurative Otitis Media

  • Acute Or Subacute Suppurative Otitis Media

  • Acute Or Subacute Purulent Otitis Media
Epiphyseal Dysplasia, Multiple, 2

  • EDM2

  • Multiple Epiphyseal Dysplasia 2

  • Dysplasia, Epiphyseal, Multiple, Type 2
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Epiphyseal Dysplasia, Multiple, 3

  • EDM3

  • Multiple Epiphyseal Dysplasia 3

  • Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy

  • Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy

  • Epiphyseal Dysplasia Multiple 3

  • Dysplasia, Epiphyseal, Multiple, Type 3
Multiple Epiphyseal Dysplasia

  • Med

  • Polyepiphyseal Dysplasia

  • Edm

  • Epiphyseal Dysplasia, Multiple, 1

  • Epiphyseal Dysplasia, Multiple, 2

  • Epiphyseal Dysplasia, Multiple, 3

  • Epiphyseal Dysplasia, Multiple, 4

  • Epiphyseal Dysplasia, Multiple, 5

  • Epiphyseal Dysplasia, Multiple

  • Edm1

  • Edm2

  • Edm3

  • Edm4

  • Edm5

  • Epiphyseal Dysplasia, Fairbank Type

  • Epiphyseal Dysplasia, Ribbing Type

  • Multiple Epiphyseal Dysplasia, Autosomal Dominant

  • Multiple Epiphyseal Dysplasia, Autosomal Recessive

  • Rmed

  • Dysplasia, Epiphyseal, Multiple

  • Osteochondrodysplasias
Suppurative Otitis Media

  • Otitis Media With Effusion - Purulent

  • Purulent Otitis Media

  • Otitis Media, Suppurative
Osteochondrodysplasia

  • Skeletal Dysplasia

  • Chondrodystrophy

  • Congenital Anomaly Of Cartilage

  • Osteochondrodysplasias

  • Cartilage Development Disorder

  • Osteochondrodysplasia Syndrome

  • Dysplasia, Skeletal

  • Mucopolysaccharidosis Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10300 PDZD11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21905 Pdzd11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28422 Pdzd11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PDZD11 VGNC VGNC:32724
Mus musculus PDZD11 MGD MGI:1919871
Rattus norvegicus PDZD11 RGD RGD:1560007
Canis familiaris PDZD11 VGNC VGNC:44399
Others PDZD11 NCBI