PLEKHA5 - pleckstrin homology domain containing A5 Gene

Also Known as PEPP2; PEPP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54477

About PLEKHA5

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:19,129,733-19,376,400 (from NCBI)

This gene has 32 transcripts (splice variants), 222 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 6.7), ovary (RPKM 5.6) and 24 other tissues.

Summary

Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to act upstream of or within reproductive system development. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHA5 Products (56)

mRNA Protein Name
NM_001143821.3 NP_001137293.2 pleckstrin homology domain-containing family A member 5 isoform 2
NM_001190860.3 NP_001177789.2 pleckstrin homology domain-containing family A member 5 isoform 3
NM_001256470.2 NP_001243399.1 pleckstrin homology domain-containing family A member 5 isoform 4
NM_001256787.2 NP_001243716.1 pleckstrin homology domain-containing family A member 5 isoform 5
NM_001385923.1 NP_001372852.1 pleckstrin homology domain-containing family A member 5 isoform 6
NM_001385924.1 NP_001372853.1 pleckstrin homology domain-containing family A member 5 isoform 7
NM_001385925.1 NP_001372854.1 pleckstrin homology domain-containing family A member 5 isoform 8
NM_001385926.1 NP_001372855.1 pleckstrin homology domain-containing family A member 5 isoform 9
NM_001385927.1 NP_001372856.1 pleckstrin homology domain-containing family A member 5 isoform 10
NM_001385928.1 NP_001372857.1 pleckstrin homology domain-containing family A member 5 isoform 11
NM_001385929.1 NP_001372858.1 pleckstrin homology domain-containing family A member 5 isoform 12
NM_001385930.1 NP_001372859.1 pleckstrin homology domain-containing family A member 5 isoform 13
NM_001385931.1 NP_001372860.1 pleckstrin homology domain-containing family A member 5 isoform 14
NM_001385932.1 NP_001372861.1 pleckstrin homology domain-containing family A member 5 isoform 15
NM_001385933.1 NP_001372862.1 pleckstrin homology domain-containing family A member 5 isoform 16
NM_001385934.1 NP_001372863.1 pleckstrin homology domain-containing family A member 5 isoform 17
NM_001385935.1 NP_001372864.1 pleckstrin homology domain-containing family A member 5 isoform 18
NM_001385936.1 NP_001372865.1 pleckstrin homology domain-containing family A member 5 isoform 19
NM_001385937.1 NP_001372866.1 pleckstrin homology domain-containing family A member 5 isoform 20
NM_001385938.1 NP_001372867.1 pleckstrin homology domain-containing family A member 5 isoform 21
NM_001385939.1 NP_001372868.1 pleckstrin homology domain-containing family A member 5 isoform 22
NM_001385940.1 NP_001372869.1 pleckstrin homology domain-containing family A member 5 isoform 23
NM_001385941.1 NP_001372870.1 pleckstrin homology domain-containing family A member 5 isoform 24
NM_001385942.1 NP_001372871.1 pleckstrin homology domain-containing family A member 5 isoform 25
NM_001385943.1 NP_001372872.1 pleckstrin homology domain-containing family A member 5 isoform 26
NM_001385944.1 NP_001372873.1 pleckstrin homology domain-containing family A member 5 isoform 27
NM_001385945.1 NP_001372874.1 pleckstrin homology domain-containing family A member 5 isoform 28
NM_001385946.1 NP_001372875.1 pleckstrin homology domain-containing family A member 5 isoform 29
NM_001385947.1 NP_001372876.1 pleckstrin homology domain-containing family A member 5 isoform 30
NM_001385948.1 NP_001372877.1 pleckstrin homology domain-containing family A member 5 isoform 31
NM_001385949.1 NP_001372878.1 pleckstrin homology domain-containing family A member 5 isoform 32
NM_001385950.1 NP_001372879.1 pleckstrin homology domain-containing family A member 5 isoform 33
NM_001385951.1 NP_001372880.1 pleckstrin homology domain-containing family A member 5 isoform 34
NM_001385952.1 NP_001372881.1 pleckstrin homology domain-containing family A member 5 isoform 35
NM_001385953.1 NP_001372882.1 pleckstrin homology domain-containing family A member 5 isoform 36
NM_001385954.1 NP_001372883.1 pleckstrin homology domain-containing family A member 5 isoform 37
NM_001385955.1 NP_001372884.1 pleckstrin homology domain-containing family A member 5 isoform 38
NM_001385956.1 NP_001372885.1 pleckstrin homology domain-containing family A member 5 isoform 38
NM_001385957.1 NP_001372886.1 pleckstrin homology domain-containing family A member 5 isoform 38
NM_001385958.1 NP_001372887.1 pleckstrin homology domain-containing family A member 5 isoform 39
NM_001385959.1 NP_001372888.1 pleckstrin homology domain-containing family A member 5 isoform 40
NM_001385960.1 NP_001372889.1 pleckstrin homology domain-containing family A member 5 isoform 41
NM_001385961.1 NP_001372890.1 pleckstrin homology domain-containing family A member 5 isoform 41
NM_001385962.1 NP_001372891.1 pleckstrin homology domain-containing family A member 5 isoform 43
NM_001385963.1 NP_001372892.1 pleckstrin homology domain-containing family A member 5 isoform 44
NM_001385964.1 NP_001372893.1 pleckstrin homology domain-containing family A member 5 isoform 45
NM_001385965.1 NP_001372894.1 pleckstrin homology domain-containing family A member 5 isoform 46
NM_001385966.1 NP_001372895.1 pleckstrin homology domain-containing family A member 5 isoform 47
NM_001385967.1 NP_001372896.1 pleckstrin homology domain-containing family A member 5 isoform 48
NM_001385968.1 NP_001372897.1 pleckstrin homology domain-containing family A member 5 isoform 2
NM_001385969.1 NP_001372898.1 pleckstrin homology domain-containing family A member 5 isoform 38
NM_001385970.1 NP_001372899.1 pleckstrin homology domain-containing family A member 5 isoform 38
NM_001385971.1 NP_001372900.1 pleckstrin homology domain-containing family A member 5 isoform 38
NM_001385972.1 NP_001372901.1 pleckstrin homology domain-containing family A member 5 isoform 38
NM_001385973.1 NP_001372902.1 pleckstrin homology domain-containing family A member 5 isoform 39
NM_019012.6 NP_061885.2 pleckstrin homology domain-containing family A member 5 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHA5 Protein Structure

WW

WW: WW domain (58 - 87)

PH

PH: PH domain (170 - 263)

  • 0
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  • 400
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  • 800
  • 1000
  • 1116 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family A member 5

  • PH domain-containing family A member 5

PLEKHA5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLEKHA5 Q9HAU0 PDZD11 Homo sapiens Q5EBL8
Y2H Array
32296183
Intra
PLEKHA5 Q9HAU0 PDZD11 Homo sapiens Q5EBL8
Y2H Prey Pooling
25416956
Intra
PLEKHA5 Q9HAU0 PDZD11 Homo sapiens Q5EBL8
Validated Y2H
25416956
Intra
PLEKHA5 Q9HAU0 PDZD11 Homo sapiens Q5EBL8
Y2H Prey Pooling
32296183
Cross
PLEKHA5 Q9HAU0 P0DTD1-PRO_0000449629 SARS-CoV-2 P0DTD1-PRO_0000449629
Y2H Array
36217030
Intra
PLEKHA5 Q9HAU0 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cleft Lip With Or Without Cleft Palate

  • Tessier Cleft Number 1,2
Blepharocheilodontic Syndrome 1

  • Blepharocheilodontic Syndrome

  • Bcd Syndrome

  • Elschnig Syndrome

  • Clefting, Ectropion, And Conical Teeth

  • Lagophthalmia With Bilateral Cleft Lip And Palate

  • Blepharo-Cheilo-Odontic Syndrome

  • Bcds

  • Ectropion, Inferior, With Cleft Lip And/Or Palate

  • Blepharo-Cheilo-Dontic Syndrome

  • BCDS1

  • Ectropion Inferior Cleft Lip And Or Palate

  • Clefting-Ectropion-Conical Teeth Syndrome

  • Ectropion Inferior-Cleft Lip And/Or Palate Syndrome

  • Lagophthalmia-Cleft Lip And Palate Syndrome

  • Blepharocheilodontic Syndrome, Type 1
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10682 PLEKHA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLEKHA5 RGD RGD:621175
Bos taurus PLEKHA5 VGNC VGNC:33007
Macaca mulatta PLEKHA5 VGNC VGNC:76135
Mus musculus PLEKHA5 MGD MGI:1923802
Felis catus PLEKHA5 VGNC VGNC:82421
Canis familiaris PLEKHA5 VGNC VGNC:44669
Others PLEKHA5 NCBI